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Simulate time-to-events for multiple scenarios

Usage

simu_time(dt, eventObj, clinInt, clinExt, seed, path)

Arguments

dt

a list of matrix generated in simu_cov containing simulated covariates information

eventObj

an object of class .eventClass generated in set_event including event information

clinInt

an object of class .clinClass generated in set_clin including internal trial information

clinExt

an object of class .clinClass generated in set_clin including external trial information

seed

the seed of R‘s random number generator. Default is the first element of .Random.seed

path

file name for saving the output including folder path

Value

a list of matrix containing simulated time-to-events information

Examples

# simulate patient-level data without covariates
# simulate survival time following weibull distribution

# simulate trial indicator and set hazard ratios
sample = set_n(ssC = 10, ssE = 20, ssExt = 40)
sample_hr <- simu_cov(ssObj = sample, HR = 1, driftHR=c(1,1.2), nsim = 10)
#> No covObj is provided.
#> The sample size for internal control, internal treatment, and external control arms are 10, 20, and 40, respectively.
#> Set seed to 10403
#> ------------------- #1of 10simulation: #1of HR =1, #1of driftHR = 1, seed =10403
#> ------------------- #2of 10simulation: #1of HR =1, #1of driftHR = 1, seed =10404
#> ------------------- #3of 10simulation: #1of HR =1, #1of driftHR = 1, seed =10405
#> ------------------- #4of 10simulation: #1of HR =1, #1of driftHR = 1, seed =10406
#> ------------------- #5of 10simulation: #1of HR =1, #1of driftHR = 1, seed =10407
#> ------------------- #6of 10simulation: #1of HR =1, #1of driftHR = 1, seed =10408
#> ------------------- #7of 10simulation: #1of HR =1, #1of driftHR = 1, seed =10409
#> ------------------- #8of 10simulation: #1of HR =1, #1of driftHR = 1, seed =10410
#> ------------------- #9of 10simulation: #1of HR =1, #1of driftHR = 1, seed =10411
#> ------------------- #10of 10simulation: #1of HR =1, #1of driftHR = 1, seed =10412
#> ------------------- #1of 10simulation: #1of HR =1, #2of driftHR = 1.2, seed =10413
#> ------------------- #2of 10simulation: #1of HR =1, #2of driftHR = 1.2, seed =10414
#> ------------------- #3of 10simulation: #1of HR =1, #2of driftHR = 1.2, seed =10415
#> ------------------- #4of 10simulation: #1of HR =1, #2of driftHR = 1.2, seed =10416
#> ------------------- #5of 10simulation: #1of HR =1, #2of driftHR = 1.2, seed =10417
#> ------------------- #6of 10simulation: #1of HR =1, #2of driftHR = 1.2, seed =10418
#> ------------------- #7of 10simulation: #1of HR =1, #2of driftHR = 1.2, seed =10419
#> ------------------- #8of 10simulation: #1of HR =1, #2of driftHR = 1.2, seed =10420
#> ------------------- #9of 10simulation: #1of HR =1, #2of driftHR = 1.2, seed =10421
#> ------------------- #10of 10simulation: #1of HR =1, #2of driftHR = 1.2, seed =10422
#> Simulated covariates are not saved.

# enrollment pattern, drop-out, analysis start time
c_int = set_clin(gamma = 2, e_itv = 10, etaC = 0.5,  CCOD = "fixed-first", CCOD_t = 64)
#> Dropout rate per unit time for treatment arm (etaE) is not specified correcly. Disregard this warning if this is for external trial. Otherwise the same dropout rate as eta is used.
c_ext = c_int

# simulate time-to-event with a weibull distribution
evt1 <- set_event(event = "weibull", shape = 0.8, lambdaC = 0.01)
simu_time(dt = sample_hr, eventObj = evt1, clinInt = c_int, clinExt = c_ext)
#> Simulating survival time... Set seed to 10403
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> Simulated time are not saved.
#> [[1]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]       1  1   0   1  0.76253459    1
#>  [2,]       1  1   0   1  3.69539278    1
#>  [3,]       1  1   0   1  2.55073045    1
#>  [4,]       1  1   0   1  0.31457275    1
#>  [5,]       1  1   0   1  1.04274046    1
#>  [6,]       1  1   0   1  6.31675736    1
#>  [7,]       1  1   0   1  0.66951076    1
#>  [8,]       1  1   0   1  3.17106585    1
#>  [9,]       1  1   0   1  4.48593523    1
#> [10,]       1  1   0   1  0.10313963    1
#> [11,]       1  1   0   1  5.76468327    1
#> [12,]       1  1   0   1  0.02480809    1
#> [13,]       1  1   0   1  6.91560984    1
#> [14,]       1  1   0   1  1.34584251    1
#> [15,]       1  1   0   1  1.41793030    1
#> [16,]       1  1   0   1  2.38139346    1
#> [17,]       1  1   0   1  0.97947383    1
#> [18,]       1  1   0   1  1.50604745    1
#> [19,]       1  1   0   1  4.76241280    1
#> [20,]       1  1   0   1  1.91276624    1
#> [21,]       1  1   0   0 12.92173382    1
#> [22,]       1  1   0   0  0.46474347    1
#> [23,]       1  1   0   0  0.95382830    1
#> [24,]       1  1   0   0  0.47862012    1
#> [25,]       1  1   0   0  1.56059880    1
#> [26,]       1  1   0   0  1.15426445    1
#> [27,]       1  1   0   0  3.20687450    1
#> [28,]       1  1   0   0  0.21758565    1
#> [29,]       1  1   0   0  0.35102087    1
#> [30,]       1  1   0   0  0.80189431    1
#> [31,]       1  1   1   0  0.99438996    1
#> [32,]       1  1   1   0  2.58013375    1
#> [33,]       1  1   1   0  0.06975786    1
#> [34,]       1  1   1   0  1.51094999    1
#> [35,]       1  1   1   0  7.08307833    1
#> [36,]       1  1   1   0  2.62559533    1
#> [37,]       1  1   1   0  1.65831799    1
#> [38,]       1  1   1   0  0.96693929    1
#> [39,]       1  1   1   0  0.23716432    1
#> [40,]       1  1   1   0  3.09122312    1
#> [41,]       1  1   1   0  0.84080084    1
#> [42,]       1  1   1   0  0.84333303    1
#> [43,]       1  1   1   0  6.53283483    1
#> [44,]       1  1   1   0  1.54900532    1
#> [45,]       1  1   1   0  1.97423165    1
#> [46,]       1  1   1   0  2.30277450    1
#> [47,]       1  1   1   0  0.12399922    1
#> [48,]       1  1   1   0  0.62455796    1
#> [49,]       1  1   1   0  0.47118664    1
#> [50,]       1  1   1   0  3.49279074    1
#> [51,]       1  1   1   0  0.33179574    1
#> [52,]       1  1   1   0  5.26129222    1
#> [53,]       1  1   1   0  1.46622206    1
#> [54,]       1  1   1   0  2.97936041    1
#> [55,]       1  1   1   0  2.41328505    1
#> [56,]       1  1   1   0  4.74419295    1
#> [57,]       1  1   1   0  2.56076630    1
#> [58,]       1  1   1   0  4.43400096    1
#> [59,]       1  1   1   0  0.21475100    1
#> [60,]       1  1   1   0  3.21981369    1
#> [61,]       1  1   1   0  4.28079315    1
#> [62,]       1  1   1   0  0.18928568    1
#> [63,]       1  1   1   0  3.56374649    1
#> [64,]       1  1   1   0  8.11511831    1
#> [65,]       1  1   1   0  0.58197146    1
#> [66,]       1  1   1   0  0.19884766    1
#> [67,]       1  1   1   0  2.60814884    1
#> [68,]       1  1   1   0  2.76585302    1
#> [69,]       1  1   1   0  0.58392686    1
#> [70,]       1  1   1   0  5.52688731    1
#> 
#> [[2]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]       1  1   0   1 2.114819301    1
#>  [2,]       1  1   0   1 1.953515559    1
#>  [3,]       1  1   0   1 2.398170119    1
#>  [4,]       1  1   0   1 1.202773339    1
#>  [5,]       1  1   0   1 1.630287435    1
#>  [6,]       1  1   0   1 0.861718923    1
#>  [7,]       1  1   0   1 1.415752711    1
#>  [8,]       1  1   0   1 1.807855103    1
#>  [9,]       1  1   0   1 3.443662193    1
#> [10,]       1  1   0   1 2.726363910    1
#> [11,]       1  1   0   1 3.780613477    1
#> [12,]       1  1   0   1 6.934935521    1
#> [13,]       1  1   0   1 2.478739608    1
#> [14,]       1  1   0   1 0.137069274    1
#> [15,]       1  1   0   1 5.842704713    1
#> [16,]       1  1   0   1 3.469582212    1
#> [17,]       1  1   0   1 0.111498843    1
#> [18,]       1  1   0   1 1.119058477    1
#> [19,]       1  1   0   1 1.580988886    1
#> [20,]       1  1   0   1 1.272147425    1
#> [21,]       1  1   0   0 1.130728490    1
#> [22,]       1  1   0   0 0.974539318    1
#> [23,]       1  1   0   0 1.905739588    1
#> [24,]       1  1   0   0 0.344170274    1
#> [25,]       1  1   0   0 1.022022431    1
#> [26,]       1  1   0   0 1.987034287    1
#> [27,]       1  1   0   0 3.769301269    1
#> [28,]       1  1   0   0 2.493451642    1
#> [29,]       1  1   0   0 0.765277998    1
#> [30,]       1  1   0   0 0.122575581    1
#> [31,]       1  1   1   0 1.843132520    1
#> [32,]       1  1   1   0 0.667929325    1
#> [33,]       1  1   1   0 1.535915091    1
#> [34,]       1  1   1   0 1.236843510    1
#> [35,]       1  1   1   0 0.931240322    1
#> [36,]       1  1   1   0 0.011111822    1
#> [37,]       1  1   1   0 2.640791450    1
#> [38,]       1  1   1   0 1.422648800    1
#> [39,]       1  1   1   0 0.244160171    0
#> [40,]       1  1   1   0 1.531001240    1
#> [41,]       1  1   1   0 0.818731466    0
#> [42,]       1  1   1   0 0.041364129    1
#> [43,]       1  1   1   0 0.619584663    1
#> [44,]       1  1   1   0 1.442063354    1
#> [45,]       1  1   1   0 1.211716602    1
#> [46,]       1  1   1   0 3.719514672    1
#> [47,]       1  1   1   0 0.571458764    1
#> [48,]       1  1   1   0 6.685834199    1
#> [49,]       1  1   1   0 1.733200281    1
#> [50,]       1  1   1   0 0.868085753    1
#> [51,]       1  1   1   0 2.302174872    1
#> [52,]       1  1   1   0 1.580238227    1
#> [53,]       1  1   1   0 3.783926572    1
#> [54,]       1  1   1   0 5.696202065    1
#> [55,]       1  1   1   0 0.656840304    1
#> [56,]       1  1   1   0 0.120495862    1
#> [57,]       1  1   1   0 2.454483654    1
#> [58,]       1  1   1   0 3.661639470    1
#> [59,]       1  1   1   0 2.256333595    1
#> [60,]       1  1   1   0 1.480296625    1
#> [61,]       1  1   1   0 0.073194170    1
#> [62,]       1  1   1   0 0.527881086    1
#> [63,]       1  1   1   0 2.966632034    1
#> [64,]       1  1   1   0 0.006966066    1
#> [65,]       1  1   1   0 1.110647786    1
#> [66,]       1  1   1   0 0.272457787    1
#> [67,]       1  1   1   0 3.857020728    1
#> [68,]       1  1   1   0 0.517826146    1
#> [69,]       1  1   1   0 0.259976864    1
#> [70,]       1  1   1   0 0.409054524    1
#> 
#> [[3]]
#>       driftHR HR ext trt         time cnsr
#>  [1,]       1  1   0   1  1.997623170    1
#>  [2,]       1  1   0   1  0.253753862    1
#>  [3,]       1  1   0   1  3.245856456    1
#>  [4,]       1  1   0   1  0.359040245    1
#>  [5,]       1  1   0   1 12.044403176    1
#>  [6,]       1  1   0   1  0.029648746    1
#>  [7,]       1  1   0   1  1.373411962    1
#>  [8,]       1  1   0   1  3.153845809    1
#>  [9,]       1  1   0   1  1.517898347    1
#> [10,]       1  1   0   1  3.722821851    1
#> [11,]       1  1   0   1  0.896307068    1
#> [12,]       1  1   0   1  0.235917864    1
#> [13,]       1  1   0   1  2.777054775    1
#> [14,]       1  1   0   1  1.722862901    1
#> [15,]       1  1   0   1  0.344980541    1
#> [16,]       1  1   0   1  0.891816727    1
#> [17,]       1  1   0   1  1.970332768    1
#> [18,]       1  1   0   1  1.780337596    1
#> [19,]       1  1   0   1  2.020878918    1
#> [20,]       1  1   0   1  0.239486868    1
#> [21,]       1  1   0   0  6.764072030    1
#> [22,]       1  1   0   0  0.340854980    1
#> [23,]       1  1   0   0  3.123411816    1
#> [24,]       1  1   0   0  0.056633457    1
#> [25,]       1  1   0   0  0.777856679    1
#> [26,]       1  1   0   0  1.354594599    1
#> [27,]       1  1   0   0  2.466303622    1
#> [28,]       1  1   0   0  2.759052548    1
#> [29,]       1  1   0   0  1.699576218    1
#> [30,]       1  1   0   0  1.143810350    1
#> [31,]       1  1   1   0  5.524034161    1
#> [32,]       1  1   1   0  0.254781677    1
#> [33,]       1  1   1   0  4.778966119    1
#> [34,]       1  1   1   0  2.744315820    1
#> [35,]       1  1   1   0  0.058755741    1
#> [36,]       1  1   1   0  0.234733717    1
#> [37,]       1  1   1   0  0.816475252    1
#> [38,]       1  1   1   0  6.169992953    1
#> [39,]       1  1   1   0  1.287879519    1
#> [40,]       1  1   1   0  4.742242583    1
#> [41,]       1  1   1   0  0.062757397    1
#> [42,]       1  1   1   0  1.587302508    1
#> [43,]       1  1   1   0  0.004270937    1
#> [44,]       1  1   1   0  2.308925208    1
#> [45,]       1  1   1   0  2.057895195    1
#> [46,]       1  1   1   0  0.792779775    1
#> [47,]       1  1   1   0  0.066122204    1
#> [48,]       1  1   1   0  1.358577055    1
#> [49,]       1  1   1   0  1.808140209    1
#> [50,]       1  1   1   0  9.612475134    1
#> [51,]       1  1   1   0  1.923005016    1
#> [52,]       1  1   1   0  3.600003615    1
#> [53,]       1  1   1   0  2.248543428    1
#> [54,]       1  1   1   0  1.782625480    1
#> [55,]       1  1   1   0  4.872563239    1
#> [56,]       1  1   1   0  0.726579097    1
#> [57,]       1  1   1   0  0.247589955    1
#> [58,]       1  1   1   0  3.567122821    1
#> [59,]       1  1   1   0  2.295245575    1
#> [60,]       1  1   1   0  0.973170074    1
#> [61,]       1  1   1   0  5.118239011    1
#> [62,]       1  1   1   0  4.267824504    1
#> [63,]       1  1   1   0  0.853806757    1
#> [64,]       1  1   1   0  0.796897074    1
#> [65,]       1  1   1   0  0.926345003    1
#> [66,]       1  1   1   0  0.115184564    0
#> [67,]       1  1   1   0  0.408574230    1
#> [68,]       1  1   1   0  3.082392530    1
#> [69,]       1  1   1   0  1.188681956    0
#> [70,]       1  1   1   0  0.841817172    1
#> 
#> [[4]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]       1  1   0   1 5.22209804    1
#>  [2,]       1  1   0   1 4.63422515    1
#>  [3,]       1  1   0   1 1.14869211    1
#>  [4,]       1  1   0   1 7.72668589    1
#>  [5,]       1  1   0   1 0.00630945    1
#>  [6,]       1  1   0   1 5.56189473    0
#>  [7,]       1  1   0   1 2.16599183    1
#>  [8,]       1  1   0   1 1.36407259    1
#>  [9,]       1  1   0   1 1.36109092    1
#> [10,]       1  1   0   1 0.09743693    1
#> [11,]       1  1   0   1 1.01015562    1
#> [12,]       1  1   0   1 0.62142798    1
#> [13,]       1  1   0   1 3.89871678    1
#> [14,]       1  1   0   1 0.59375766    1
#> [15,]       1  1   0   1 2.47111078    1
#> [16,]       1  1   0   1 2.96259727    1
#> [17,]       1  1   0   1 1.83551921    1
#> [18,]       1  1   0   1 0.98952267    1
#> [19,]       1  1   0   1 1.32074906    1
#> [20,]       1  1   0   1 0.21159563    1
#> [21,]       1  1   0   0 0.64260529    0
#> [22,]       1  1   0   0 0.39929137    1
#> [23,]       1  1   0   0 1.11218423    1
#> [24,]       1  1   0   0 7.05000625    1
#> [25,]       1  1   0   0 0.46356915    1
#> [26,]       1  1   0   0 1.21917831    1
#> [27,]       1  1   0   0 0.65260754    1
#> [28,]       1  1   0   0 0.07603153    1
#> [29,]       1  1   0   0 0.41676345    1
#> [30,]       1  1   0   0 0.45632308    1
#> [31,]       1  1   1   0 2.32608709    1
#> [32,]       1  1   1   0 4.06851229    1
#> [33,]       1  1   1   0 0.67034051    1
#> [34,]       1  1   1   0 4.64498495    1
#> [35,]       1  1   1   0 1.05069932    1
#> [36,]       1  1   1   0 2.80563975    1
#> [37,]       1  1   1   0 0.04669515    1
#> [38,]       1  1   1   0 0.24622397    1
#> [39,]       1  1   1   0 8.55748083    1
#> [40,]       1  1   1   0 0.30649763    1
#> [41,]       1  1   1   0 2.27576446    1
#> [42,]       1  1   1   0 2.20659397    1
#> [43,]       1  1   1   0 1.71697019    1
#> [44,]       1  1   1   0 2.03654622    1
#> [45,]       1  1   1   0 0.77880873    1
#> [46,]       1  1   1   0 0.81470630    1
#> [47,]       1  1   1   0 0.15342011    1
#> [48,]       1  1   1   0 2.01689792    1
#> [49,]       1  1   1   0 0.91296193    1
#> [50,]       1  1   1   0 0.70783159    1
#> [51,]       1  1   1   0 1.14935005    1
#> [52,]       1  1   1   0 2.17995680    1
#> [53,]       1  1   1   0 3.82088409    1
#> [54,]       1  1   1   0 0.22293155    1
#> [55,]       1  1   1   0 2.41833442    1
#> [56,]       1  1   1   0 4.47934276    1
#> [57,]       1  1   1   0 0.34708670    1
#> [58,]       1  1   1   0 0.24429353    1
#> [59,]       1  1   1   0 2.43934288    1
#> [60,]       1  1   1   0 0.33080672    1
#> [61,]       1  1   1   0 1.55840788    1
#> [62,]       1  1   1   0 4.51860553    1
#> [63,]       1  1   1   0 1.89094240    1
#> [64,]       1  1   1   0 1.25642198    1
#> [65,]       1  1   1   0 0.72453592    1
#> [66,]       1  1   1   0 7.72269390    1
#> [67,]       1  1   1   0 4.99006486    1
#> [68,]       1  1   1   0 5.83431488    1
#> [69,]       1  1   1   0 2.26746487    1
#> [70,]       1  1   1   0 3.28334162    1
#> 
#> [[5]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]       1  1   0   1  5.45819129    1
#>  [2,]       1  1   0   1  2.18808145    1
#>  [3,]       1  1   0   1  2.54978609    1
#>  [4,]       1  1   0   1  2.20985904    1
#>  [5,]       1  1   0   1  0.15839760    1
#>  [6,]       1  1   0   1  1.53946571    1
#>  [7,]       1  1   0   1  1.32177394    1
#>  [8,]       1  1   0   1  3.93302633    1
#>  [9,]       1  1   0   1  1.34141308    1
#> [10,]       1  1   0   1  0.22237919    1
#> [11,]       1  1   0   1  1.66128482    1
#> [12,]       1  1   0   1  2.08348545    1
#> [13,]       1  1   0   1  1.94666076    1
#> [14,]       1  1   0   1  0.17030135    1
#> [15,]       1  1   0   1  0.01456245    1
#> [16,]       1  1   0   1  0.02982318    1
#> [17,]       1  1   0   1  0.92295109    1
#> [18,]       1  1   0   1  0.50678856    1
#> [19,]       1  1   0   1  0.15775004    1
#> [20,]       1  1   0   1  0.72114221    1
#> [21,]       1  1   0   0  1.02941416    1
#> [22,]       1  1   0   0  0.56882388    1
#> [23,]       1  1   0   0  1.39716127    1
#> [24,]       1  1   0   0  0.32599690    1
#> [25,]       1  1   0   0  1.03658487    1
#> [26,]       1  1   0   0 13.99454865    1
#> [27,]       1  1   0   0  1.00914399    1
#> [28,]       1  1   0   0  2.58310317    1
#> [29,]       1  1   0   0  1.20181819    1
#> [30,]       1  1   0   0  0.50860674    1
#> [31,]       1  1   1   0  1.74978910    1
#> [32,]       1  1   1   0  0.82664697    1
#> [33,]       1  1   1   0  3.26744652    1
#> [34,]       1  1   1   0  7.12501119    1
#> [35,]       1  1   1   0  0.43026548    1
#> [36,]       1  1   1   0  0.79795924    1
#> [37,]       1  1   1   0  7.91697438    1
#> [38,]       1  1   1   0  3.13336434    1
#> [39,]       1  1   1   0  2.68454343    1
#> [40,]       1  1   1   0  0.35422173    1
#> [41,]       1  1   1   0  0.25529938    1
#> [42,]       1  1   1   0  4.86226005    1
#> [43,]       1  1   1   0  5.59430923    1
#> [44,]       1  1   1   0  4.95063289    1
#> [45,]       1  1   1   0  0.11516023    1
#> [46,]       1  1   1   0  0.19342646    1
#> [47,]       1  1   1   0  1.67319367    1
#> [48,]       1  1   1   0  2.77683787    1
#> [49,]       1  1   1   0  0.98749740    1
#> [50,]       1  1   1   0  0.25896831    1
#> [51,]       1  1   1   0  1.85554195    1
#> [52,]       1  1   1   0  1.64696588    1
#> [53,]       1  1   1   0  2.14862503    1
#> [54,]       1  1   1   0  2.29978015    1
#> [55,]       1  1   1   0  0.75648325    1
#> [56,]       1  1   1   0  4.52485075    1
#> [57,]       1  1   1   0  5.03763859    1
#> [58,]       1  1   1   0  1.40081353    1
#> [59,]       1  1   1   0  0.06349888    1
#> [60,]       1  1   1   0  0.90224548    1
#> [61,]       1  1   1   0  0.30477629    1
#> [62,]       1  1   1   0  0.62092895    1
#> [63,]       1  1   1   0  1.17581018    1
#> [64,]       1  1   1   0  8.00693990    1
#> [65,]       1  1   1   0  2.78690169    1
#> [66,]       1  1   1   0  0.39641417    1
#> [67,]       1  1   1   0  0.26774797    1
#> [68,]       1  1   1   0  6.18908366    1
#> [69,]       1  1   1   0  5.34483796    1
#> [70,]       1  1   1   0  0.51833999    1
#> 
#> [[6]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]       1  1   0   1  2.60651627    1
#>  [2,]       1  1   0   1  2.27682957    1
#>  [3,]       1  1   0   1  2.38504091    1
#>  [4,]       1  1   0   1  2.51289431    1
#>  [5,]       1  1   0   1  0.07733324    1
#>  [6,]       1  1   0   1  0.26052591    1
#>  [7,]       1  1   0   1  0.06432156    1
#>  [8,]       1  1   0   1  0.73963615    1
#>  [9,]       1  1   0   1  2.65852603    1
#> [10,]       1  1   0   1  1.65877406    1
#> [11,]       1  1   0   1  0.62205010    1
#> [12,]       1  1   0   1  1.16395064    1
#> [13,]       1  1   0   1  1.70971171    1
#> [14,]       1  1   0   1  2.16639960    1
#> [15,]       1  1   0   1  0.23872908    1
#> [16,]       1  1   0   1  1.76865952    1
#> [17,]       1  1   0   1  1.13008740    1
#> [18,]       1  1   0   1  0.59508519    1
#> [19,]       1  1   0   1  2.40716960    1
#> [20,]       1  1   0   1  2.82389199    1
#> [21,]       1  1   0   0  1.17069151    1
#> [22,]       1  1   0   0  4.17294251    1
#> [23,]       1  1   0   0  4.60141248    1
#> [24,]       1  1   0   0  4.12689771    1
#> [25,]       1  1   0   0  0.23792921    1
#> [26,]       1  1   0   0  0.63833628    1
#> [27,]       1  1   0   0  1.95403313    1
#> [28,]       1  1   0   0  2.30897288    1
#> [29,]       1  1   0   0  2.61011791    1
#> [30,]       1  1   0   0  0.19979987    0
#> [31,]       1  1   1   0  2.20490600    1
#> [32,]       1  1   1   0  0.51813334    1
#> [33,]       1  1   1   0  1.21143545    1
#> [34,]       1  1   1   0  3.83118758    1
#> [35,]       1  1   1   0  1.81165273    1
#> [36,]       1  1   1   0  2.67515896    1
#> [37,]       1  1   1   0  0.52961824    1
#> [38,]       1  1   1   0  5.55346273    1
#> [39,]       1  1   1   0  1.17684250    1
#> [40,]       1  1   1   0  3.46774428    1
#> [41,]       1  1   1   0  0.63717121    1
#> [42,]       1  1   1   0  0.37929555    1
#> [43,]       1  1   1   0  2.84322649    1
#> [44,]       1  1   1   0  2.34349439    1
#> [45,]       1  1   1   0  2.39019614    1
#> [46,]       1  1   1   0  2.00482482    1
#> [47,]       1  1   1   0  0.71456205    1
#> [48,]       1  1   1   0  1.66911143    1
#> [49,]       1  1   1   0  1.28470905    1
#> [50,]       1  1   1   0  2.29280648    1
#> [51,]       1  1   1   0  0.53690220    1
#> [52,]       1  1   1   0  2.15894538    1
#> [53,]       1  1   1   0  4.09100910    1
#> [54,]       1  1   1   0  0.72011547    1
#> [55,]       1  1   1   0  0.92499088    1
#> [56,]       1  1   1   0  2.11265907    0
#> [57,]       1  1   1   0  5.08133796    1
#> [58,]       1  1   1   0  1.81548868    1
#> [59,]       1  1   1   0  0.67108759    1
#> [60,]       1  1   1   0  3.89611050    1
#> [61,]       1  1   1   0  2.54460214    1
#> [62,]       1  1   1   0  0.72666006    1
#> [63,]       1  1   1   0  1.04858835    1
#> [64,]       1  1   1   0  1.83835646    1
#> [65,]       1  1   1   0  4.04512870    1
#> [66,]       1  1   1   0  6.44779779    1
#> [67,]       1  1   1   0 11.72677061    1
#> [68,]       1  1   1   0  1.17120320    1
#> [69,]       1  1   1   0  0.05938425    1
#> [70,]       1  1   1   0  2.14627496    1
#> 
#> [[7]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]       1  1   0   1 1.52192306    1
#>  [2,]       1  1   0   1 0.42628454    1
#>  [3,]       1  1   0   1 4.45932363    1
#>  [4,]       1  1   0   1 2.61569671    1
#>  [5,]       1  1   0   1 0.86214003    1
#>  [6,]       1  1   0   1 1.41327091    1
#>  [7,]       1  1   0   1 0.28246267    1
#>  [8,]       1  1   0   1 3.60612115    1
#>  [9,]       1  1   0   1 2.10382306    1
#> [10,]       1  1   0   1 0.24555834    1
#> [11,]       1  1   0   1 3.51496445    1
#> [12,]       1  1   0   1 0.01736248    1
#> [13,]       1  1   0   1 0.83935051    1
#> [14,]       1  1   0   1 0.97291662    1
#> [15,]       1  1   0   1 1.80584437    1
#> [16,]       1  1   0   1 1.18236139    1
#> [17,]       1  1   0   1 2.78530653    1
#> [18,]       1  1   0   1 1.03331708    1
#> [19,]       1  1   0   1 1.27630043    1
#> [20,]       1  1   0   1 3.10759203    1
#> [21,]       1  1   0   0 1.48679078    1
#> [22,]       1  1   0   0 2.29718015    1
#> [23,]       1  1   0   0 2.83605119    1
#> [24,]       1  1   0   0 1.95737178    1
#> [25,]       1  1   0   0 1.45540612    1
#> [26,]       1  1   0   0 2.24325589    1
#> [27,]       1  1   0   0 5.95947613    1
#> [28,]       1  1   0   0 0.01741881    1
#> [29,]       1  1   0   0 0.58836996    1
#> [30,]       1  1   0   0 5.51835241    1
#> [31,]       1  1   1   0 0.08948287    1
#> [32,]       1  1   1   0 5.43557478    1
#> [33,]       1  1   1   0 0.32870108    1
#> [34,]       1  1   1   0 1.21898818    1
#> [35,]       1  1   1   0 0.60634790    1
#> [36,]       1  1   1   0 0.73999765    1
#> [37,]       1  1   1   0 0.17446830    1
#> [38,]       1  1   1   0 0.47350687    1
#> [39,]       1  1   1   0 2.58720717    1
#> [40,]       1  1   1   0 0.75427608    1
#> [41,]       1  1   1   0 0.81363073    1
#> [42,]       1  1   1   0 0.60437516    1
#> [43,]       1  1   1   0 0.68425695    1
#> [44,]       1  1   1   0 1.29160825    1
#> [45,]       1  1   1   0 1.88656873    1
#> [46,]       1  1   1   0 0.07799313    1
#> [47,]       1  1   1   0 3.14428148    1
#> [48,]       1  1   1   0 0.86073023    1
#> [49,]       1  1   1   0 2.04639949    1
#> [50,]       1  1   1   0 2.60860079    1
#> [51,]       1  1   1   0 0.91097510    1
#> [52,]       1  1   1   0 3.04891704    1
#> [53,]       1  1   1   0 0.43668328    1
#> [54,]       1  1   1   0 1.00658369    1
#> [55,]       1  1   1   0 5.55779153    1
#> [56,]       1  1   1   0 2.84982439    1
#> [57,]       1  1   1   0 1.20527343    1
#> [58,]       1  1   1   0 1.33526478    1
#> [59,]       1  1   1   0 1.41729343    1
#> [60,]       1  1   1   0 1.85978825    1
#> [61,]       1  1   1   0 3.14649205    1
#> [62,]       1  1   1   0 2.99673728    1
#> [63,]       1  1   1   0 1.21326767    1
#> [64,]       1  1   1   0 0.87059698    1
#> [65,]       1  1   1   0 2.76728515    1
#> [66,]       1  1   1   0 2.89701803    1
#> [67,]       1  1   1   0 0.13135251    1
#> [68,]       1  1   1   0 0.16585954    1
#> [69,]       1  1   1   0 0.51752199    1
#> [70,]       1  1   1   0 0.11576548    1
#> 
#> [[8]]
#>       driftHR HR ext trt         time cnsr
#>  [1,]       1  1   0   1  0.001342084    1
#>  [2,]       1  1   0   1  2.429698944    1
#>  [3,]       1  1   0   1  6.715848247    1
#>  [4,]       1  1   0   1  0.235914950    1
#>  [5,]       1  1   0   1  0.964363127    1
#>  [6,]       1  1   0   1  1.849526117    1
#>  [7,]       1  1   0   1  3.962358236    1
#>  [8,]       1  1   0   1  0.730092721    1
#>  [9,]       1  1   0   1  1.272058247    1
#> [10,]       1  1   0   1  2.824909288    1
#> [11,]       1  1   0   1  7.151102524    1
#> [12,]       1  1   0   1  1.098462368    1
#> [13,]       1  1   0   1  1.467047917    1
#> [14,]       1  1   0   1  0.179471738    1
#> [15,]       1  1   0   1  3.324483618    1
#> [16,]       1  1   0   1  0.245945966    1
#> [17,]       1  1   0   1  1.148730231    1
#> [18,]       1  1   0   1  0.813589713    1
#> [19,]       1  1   0   1  0.072099904    1
#> [20,]       1  1   0   1  0.378318283    1
#> [21,]       1  1   0   0  3.933732793    1
#> [22,]       1  1   0   0  2.014533587    1
#> [23,]       1  1   0   0  0.678126944    1
#> [24,]       1  1   0   0  0.309673613    1
#> [25,]       1  1   0   0  0.175746528    1
#> [26,]       1  1   0   0  0.812072812    1
#> [27,]       1  1   0   0  1.030672973    1
#> [28,]       1  1   0   0  0.006847956    1
#> [29,]       1  1   0   0  5.509393032    1
#> [30,]       1  1   0   0  1.778471386    1
#> [31,]       1  1   1   0  6.912297696    1
#> [32,]       1  1   1   0  0.384120832    1
#> [33,]       1  1   1   0  2.360851614    1
#> [34,]       1  1   1   0  1.142113071    1
#> [35,]       1  1   1   0  0.382813072    1
#> [36,]       1  1   1   0  0.339757937    1
#> [37,]       1  1   1   0  2.432413090    1
#> [38,]       1  1   1   0  1.122593891    1
#> [39,]       1  1   1   0  2.414472232    1
#> [40,]       1  1   1   0  1.705257366    1
#> [41,]       1  1   1   0  0.988883106    1
#> [42,]       1  1   1   0  1.809442123    1
#> [43,]       1  1   1   0  0.159295182    1
#> [44,]       1  1   1   0  2.496314220    1
#> [45,]       1  1   1   0  0.729462539    1
#> [46,]       1  1   1   0  4.279122267    1
#> [47,]       1  1   1   0  0.311150549    1
#> [48,]       1  1   1   0  0.441548530    1
#> [49,]       1  1   1   0  3.544328272    1
#> [50,]       1  1   1   0  1.366449430    1
#> [51,]       1  1   1   0  0.218585799    1
#> [52,]       1  1   1   0  5.455861944    1
#> [53,]       1  1   1   0  3.293792038    1
#> [54,]       1  1   1   0  2.608978799    1
#> [55,]       1  1   1   0  2.894717537    1
#> [56,]       1  1   1   0  7.960256438    1
#> [57,]       1  1   1   0  2.148886342    1
#> [58,]       1  1   1   0  6.591771997    1
#> [59,]       1  1   1   0  4.460350182    1
#> [60,]       1  1   1   0  4.842784550    1
#> [61,]       1  1   1   0  3.139305777    1
#> [62,]       1  1   1   0  2.351649793    1
#> [63,]       1  1   1   0  0.880463036    1
#> [64,]       1  1   1   0  1.246562589    1
#> [65,]       1  1   1   0  3.530980896    1
#> [66,]       1  1   1   0  1.022782520    1
#> [67,]       1  1   1   0  0.942160271    1
#> [68,]       1  1   1   0  6.665294796    1
#> [69,]       1  1   1   0  3.562228899    1
#> [70,]       1  1   1   0 11.642852514    1
#> 
#> [[9]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]       1  1   0   1 1.13652654    1
#>  [2,]       1  1   0   1 0.32038180    1
#>  [3,]       1  1   0   1 2.31909397    1
#>  [4,]       1  1   0   1 0.15326106    1
#>  [5,]       1  1   0   1 1.75279099    1
#>  [6,]       1  1   0   1 2.32414935    1
#>  [7,]       1  1   0   1 0.35882870    1
#>  [8,]       1  1   0   1 0.46546949    1
#>  [9,]       1  1   0   1 0.21118864    1
#> [10,]       1  1   0   1 0.53558670    1
#> [11,]       1  1   0   1 0.14081581    1
#> [12,]       1  1   0   1 2.37036728    1
#> [13,]       1  1   0   1 0.13041611    1
#> [14,]       1  1   0   1 5.63199492    1
#> [15,]       1  1   0   1 2.12874691    1
#> [16,]       1  1   0   1 5.38522861    1
#> [17,]       1  1   0   1 2.29589652    1
#> [18,]       1  1   0   1 6.68708916    1
#> [19,]       1  1   0   1 0.97081533    1
#> [20,]       1  1   0   1 0.80344464    1
#> [21,]       1  1   0   0 2.89765651    1
#> [22,]       1  1   0   0 4.45145247    1
#> [23,]       1  1   0   0 0.44904407    1
#> [24,]       1  1   0   0 6.49477705    1
#> [25,]       1  1   0   0 0.42129787    1
#> [26,]       1  1   0   0 2.92652697    1
#> [27,]       1  1   0   0 3.06054820    1
#> [28,]       1  1   0   0 1.95260303    1
#> [29,]       1  1   0   0 3.57882164    1
#> [30,]       1  1   0   0 0.19365372    1
#> [31,]       1  1   1   0 1.78007124    1
#> [32,]       1  1   1   0 2.56194829    1
#> [33,]       1  1   1   0 0.28359410    1
#> [34,]       1  1   1   0 4.73052808    1
#> [35,]       1  1   1   0 2.83052386    1
#> [36,]       1  1   1   0 0.70410323    1
#> [37,]       1  1   1   0 0.81446761    1
#> [38,]       1  1   1   0 1.00891901    1
#> [39,]       1  1   1   0 0.23219681    1
#> [40,]       1  1   1   0 5.25223491    1
#> [41,]       1  1   1   0 4.36434838    1
#> [42,]       1  1   1   0 3.41954250    1
#> [43,]       1  1   1   0 0.07700413    1
#> [44,]       1  1   1   0 1.72318146    1
#> [45,]       1  1   1   0 0.43071312    1
#> [46,]       1  1   1   0 0.01506365    1
#> [47,]       1  1   1   0 2.08255971    1
#> [48,]       1  1   1   0 1.17520443    1
#> [49,]       1  1   1   0 6.63179487    1
#> [50,]       1  1   1   0 0.12136436    1
#> [51,]       1  1   1   0 1.82863724    1
#> [52,]       1  1   1   0 2.01440875    1
#> [53,]       1  1   1   0 6.48354356    1
#> [54,]       1  1   1   0 1.00260881    1
#> [55,]       1  1   1   0 0.49882109    1
#> [56,]       1  1   1   0 0.41458614    1
#> [57,]       1  1   1   0 1.84866183    1
#> [58,]       1  1   1   0 0.23954044    1
#> [59,]       1  1   1   0 1.16587978    1
#> [60,]       1  1   1   0 0.32465935    1
#> [61,]       1  1   1   0 0.31879080    1
#> [62,]       1  1   1   0 3.77437919    1
#> [63,]       1  1   1   0 2.20690123    1
#> [64,]       1  1   1   0 0.31120733    1
#> [65,]       1  1   1   0 8.21128483    1
#> [66,]       1  1   1   0 1.05919000    1
#> [67,]       1  1   1   0 2.38415150    1
#> [68,]       1  1   1   0 5.95310527    1
#> [69,]       1  1   1   0 0.35817263    1
#> [70,]       1  1   1   0 2.70331200    1
#> 
#> [[10]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]       1  1   0   1  1.17611898    1
#>  [2,]       1  1   0   1  0.70913942    1
#>  [3,]       1  1   0   1  3.43343166    1
#>  [4,]       1  1   0   1  0.18883777    1
#>  [5,]       1  1   0   1  2.25457443    1
#>  [6,]       1  1   0   1  1.97097302    1
#>  [7,]       1  1   0   1  2.83945154    1
#>  [8,]       1  1   0   1  3.07097500    1
#>  [9,]       1  1   0   1  5.01977328    1
#> [10,]       1  1   0   1  1.61065592    1
#> [11,]       1  1   0   1  1.92145226    1
#> [12,]       1  1   0   1  0.44986843    1
#> [13,]       1  1   0   1  2.10090835    1
#> [14,]       1  1   0   1  1.22212513    1
#> [15,]       1  1   0   1  3.21939699    1
#> [16,]       1  1   0   1  4.35445460    1
#> [17,]       1  1   0   1  1.62852722    1
#> [18,]       1  1   0   1  0.41894748    1
#> [19,]       1  1   0   1  1.23147832    1
#> [20,]       1  1   0   1  3.20074176    1
#> [21,]       1  1   0   0  2.86044932    1
#> [22,]       1  1   0   0  1.05749077    1
#> [23,]       1  1   0   0  4.33676870    1
#> [24,]       1  1   0   0  3.09258277    1
#> [25,]       1  1   0   0  0.88958895    1
#> [26,]       1  1   0   0  6.02694258    1
#> [27,]       1  1   0   0  2.36838564    1
#> [28,]       1  1   0   0  0.12689030    1
#> [29,]       1  1   0   0  1.05486920    1
#> [30,]       1  1   0   0  2.22567116    1
#> [31,]       1  1   1   0  0.41143789    1
#> [32,]       1  1   1   0  2.62090631    1
#> [33,]       1  1   1   0  1.50792708    1
#> [34,]       1  1   1   0  6.47534877    1
#> [35,]       1  1   1   0  1.28210848    1
#> [36,]       1  1   1   0  0.07548353    1
#> [37,]       1  1   1   0  1.01109790    1
#> [38,]       1  1   1   0  0.78901440    1
#> [39,]       1  1   1   0  2.63053876    1
#> [40,]       1  1   1   0  0.61924971    1
#> [41,]       1  1   1   0  2.53585657    1
#> [42,]       1  1   1   0  2.07979654    1
#> [43,]       1  1   1   0  1.93693455    1
#> [44,]       1  1   1   0  0.29031341    1
#> [45,]       1  1   1   0  1.42673844    1
#> [46,]       1  1   1   0  2.45457493    1
#> [47,]       1  1   1   0  3.86026499    1
#> [48,]       1  1   1   0  0.88408052    1
#> [49,]       1  1   1   0  1.19547888    1
#> [50,]       1  1   1   0  0.72893216    1
#> [51,]       1  1   1   0  0.51664102    1
#> [52,]       1  1   1   0  3.88799960    1
#> [53,]       1  1   1   0  2.59956722    1
#> [54,]       1  1   1   0  1.36580752    1
#> [55,]       1  1   1   0  4.39125693    1
#> [56,]       1  1   1   0  0.67636760    1
#> [57,]       1  1   1   0  1.35245643    1
#> [58,]       1  1   1   0 11.14187938    1
#> [59,]       1  1   1   0  1.40774404    1
#> [60,]       1  1   1   0  3.46125811    1
#> [61,]       1  1   1   0  2.83681835    1
#> [62,]       1  1   1   0  0.68527321    1
#> [63,]       1  1   1   0  1.89861906    1
#> [64,]       1  1   1   0  3.12240189    1
#> [65,]       1  1   1   0  1.03056576    1
#> [66,]       1  1   1   0  0.96330373    1
#> [67,]       1  1   1   0  1.49203737    1
#> [68,]       1  1   1   0  0.93894396    1
#> [69,]       1  1   1   0  0.54109144    1
#> [70,]       1  1   1   0  2.56660255    1
#> 
#> [[11]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]     1.2  1   0   1 0.249242079    1
#>  [2,]     1.2  1   0   1 2.042058265    1
#>  [3,]     1.2  1   0   1 0.048367975    1
#>  [4,]     1.2  1   0   1 0.790969354    1
#>  [5,]     1.2  1   0   1 1.119771578    1
#>  [6,]     1.2  1   0   1 3.443386119    1
#>  [7,]     1.2  1   0   1 4.052455738    1
#>  [8,]     1.2  1   0   1 3.839851681    1
#>  [9,]     1.2  1   0   1 1.863473958    1
#> [10,]     1.2  1   0   1 3.479317061    1
#> [11,]     1.2  1   0   1 1.335391284    1
#> [12,]     1.2  1   0   1 2.111216742    1
#> [13,]     1.2  1   0   1 0.005234527    1
#> [14,]     1.2  1   0   1 7.906050037    1
#> [15,]     1.2  1   0   1 4.272420224    1
#> [16,]     1.2  1   0   1 1.809842489    1
#> [17,]     1.2  1   0   1 1.266690006    1
#> [18,]     1.2  1   0   1 1.867775423    1
#> [19,]     1.2  1   0   1 0.827040184    1
#> [20,]     1.2  1   0   1 0.139053610    1
#> [21,]     1.2  1   0   0 0.495321625    1
#> [22,]     1.2  1   0   0 0.422714303    1
#> [23,]     1.2  1   0   0 1.669025401    1
#> [24,]     1.2  1   0   0 3.878836043    1
#> [25,]     1.2  1   0   0 1.030448275    1
#> [26,]     1.2  1   0   0 2.504196396    1
#> [27,]     1.2  1   0   0 1.655476371    1
#> [28,]     1.2  1   0   0 2.038572455    1
#> [29,]     1.2  1   0   0 3.229661742    1
#> [30,]     1.2  1   0   0 0.124059890    1
#> [31,]     1.2  1   1   0 0.872397064    1
#> [32,]     1.2  1   1   0 4.866986137    1
#> [33,]     1.2  1   1   0 1.447199600    1
#> [34,]     1.2  1   1   0 1.672512076    1
#> [35,]     1.2  1   1   0 0.524908172    1
#> [36,]     1.2  1   1   0 1.909101361    1
#> [37,]     1.2  1   1   0 2.209106906    1
#> [38,]     1.2  1   1   0 5.886559948    1
#> [39,]     1.2  1   1   0 1.670775258    1
#> [40,]     1.2  1   1   0 2.039066294    1
#> [41,]     1.2  1   1   0 3.727933810    1
#> [42,]     1.2  1   1   0 2.866720492    1
#> [43,]     1.2  1   1   0 0.127764682    1
#> [44,]     1.2  1   1   0 1.769414343    1
#> [45,]     1.2  1   1   0 0.128324638    1
#> [46,]     1.2  1   1   0 3.514867838    1
#> [47,]     1.2  1   1   0 0.837867416    1
#> [48,]     1.2  1   1   0 0.507035146    1
#> [49,]     1.2  1   1   0 1.819777449    1
#> [50,]     1.2  1   1   0 0.527807408    1
#> [51,]     1.2  1   1   0 0.220032750    1
#> [52,]     1.2  1   1   0 1.772336224    1
#> [53,]     1.2  1   1   0 0.144622889    1
#> [54,]     1.2  1   1   0 0.532160702    1
#> [55,]     1.2  1   1   0 0.864766274    1
#> [56,]     1.2  1   1   0 2.489347799    1
#> [57,]     1.2  1   1   0 1.063934920    1
#> [58,]     1.2  1   1   0 0.652282180    1
#> [59,]     1.2  1   1   0 2.600226182    1
#> [60,]     1.2  1   1   0 1.095689783    0
#> [61,]     1.2  1   1   0 0.753531339    1
#> [62,]     1.2  1   1   0 0.115275808    1
#> [63,]     1.2  1   1   0 4.339982848    1
#> [64,]     1.2  1   1   0 0.136562041    1
#> [65,]     1.2  1   1   0 0.963815276    1
#> [66,]     1.2  1   1   0 0.526268344    1
#> [67,]     1.2  1   1   0 1.068482833    1
#> [68,]     1.2  1   1   0 1.071926565    1
#> [69,]     1.2  1   1   0 0.862817984    1
#> [70,]     1.2  1   1   0 0.521924143    1
#> 
#> [[12]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]     1.2  1   0   1 0.85601331    1
#>  [2,]     1.2  1   0   1 0.99678186    1
#>  [3,]     1.2  1   0   1 1.31324194    1
#>  [4,]     1.2  1   0   1 0.97360541    1
#>  [5,]     1.2  1   0   1 0.20617358    1
#>  [6,]     1.2  1   0   1 3.28981956    1
#>  [7,]     1.2  1   0   1 1.90209690    1
#>  [8,]     1.2  1   0   1 1.95988515    1
#>  [9,]     1.2  1   0   1 0.50165990    1
#> [10,]     1.2  1   0   1 0.20734773    1
#> [11,]     1.2  1   0   1 0.08544395    1
#> [12,]     1.2  1   0   1 4.28496455    1
#> [13,]     1.2  1   0   1 1.34954309    1
#> [14,]     1.2  1   0   1 1.19422421    1
#> [15,]     1.2  1   0   1 1.34713284    1
#> [16,]     1.2  1   0   1 4.03222963    1
#> [17,]     1.2  1   0   1 3.63394362    1
#> [18,]     1.2  1   0   1 2.53978986    1
#> [19,]     1.2  1   0   1 0.85376509    1
#> [20,]     1.2  1   0   1 0.08083600    1
#> [21,]     1.2  1   0   0 2.58168694    1
#> [22,]     1.2  1   0   0 0.06114425    1
#> [23,]     1.2  1   0   0 1.24485493    1
#> [24,]     1.2  1   0   0 0.96093157    1
#> [25,]     1.2  1   0   0 0.07202821    1
#> [26,]     1.2  1   0   0 0.43546341    1
#> [27,]     1.2  1   0   0 3.65499707    1
#> [28,]     1.2  1   0   0 1.92072270    1
#> [29,]     1.2  1   0   0 0.21991526    1
#> [30,]     1.2  1   0   0 2.47458491    1
#> [31,]     1.2  1   1   0 2.80040738    1
#> [32,]     1.2  1   1   0 0.88230485    1
#> [33,]     1.2  1   1   0 7.04598694    1
#> [34,]     1.2  1   1   0 0.99840521    1
#> [35,]     1.2  1   1   0 0.83208783    1
#> [36,]     1.2  1   1   0 1.95070820    1
#> [37,]     1.2  1   1   0 1.31919902    1
#> [38,]     1.2  1   1   0 1.82713134    1
#> [39,]     1.2  1   1   0 1.42783205    1
#> [40,]     1.2  1   1   0 0.25961839    1
#> [41,]     1.2  1   1   0 7.20229868    1
#> [42,]     1.2  1   1   0 1.03454111    1
#> [43,]     1.2  1   1   0 0.09014782    1
#> [44,]     1.2  1   1   0 0.66185574    1
#> [45,]     1.2  1   1   0 0.14519348    1
#> [46,]     1.2  1   1   0 0.64193764    1
#> [47,]     1.2  1   1   0 1.63426094    1
#> [48,]     1.2  1   1   0 1.04658092    1
#> [49,]     1.2  1   1   0 0.24349620    1
#> [50,]     1.2  1   1   0 0.41730474    1
#> [51,]     1.2  1   1   0 2.12857332    1
#> [52,]     1.2  1   1   0 0.36253961    1
#> [53,]     1.2  1   1   0 5.85618319    1
#> [54,]     1.2  1   1   0 1.67893784    1
#> [55,]     1.2  1   1   0 5.62149767    1
#> [56,]     1.2  1   1   0 1.49022036    1
#> [57,]     1.2  1   1   0 0.31496318    1
#> [58,]     1.2  1   1   0 0.63117596    1
#> [59,]     1.2  1   1   0 1.88294809    1
#> [60,]     1.2  1   1   0 3.70900188    1
#> [61,]     1.2  1   1   0 0.93992748    1
#> [62,]     1.2  1   1   0 1.02114533    1
#> [63,]     1.2  1   1   0 1.67079589    1
#> [64,]     1.2  1   1   0 0.81366819    1
#> [65,]     1.2  1   1   0 8.66279292    1
#> [66,]     1.2  1   1   0 2.76561921    1
#> [67,]     1.2  1   1   0 2.84350285    1
#> [68,]     1.2  1   1   0 0.17416219    1
#> [69,]     1.2  1   1   0 5.23248576    1
#> [70,]     1.2  1   1   0 5.15266089    1
#> 
#> [[13]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]     1.2  1   0   1  0.17030087    1
#>  [2,]     1.2  1   0   1 13.79077908    1
#>  [3,]     1.2  1   0   1  0.07485766    1
#>  [4,]     1.2  1   0   1  4.49010790    1
#>  [5,]     1.2  1   0   1  1.89925616    1
#>  [6,]     1.2  1   0   1  0.44850911    1
#>  [7,]     1.2  1   0   1  4.07341230    1
#>  [8,]     1.2  1   0   1  0.73087019    1
#>  [9,]     1.2  1   0   1  0.22152275    1
#> [10,]     1.2  1   0   1  1.15118959    1
#> [11,]     1.2  1   0   1  2.86017945    1
#> [12,]     1.2  1   0   1  1.62998102    1
#> [13,]     1.2  1   0   1  1.65786767    1
#> [14,]     1.2  1   0   1  3.51715653    1
#> [15,]     1.2  1   0   1  7.58515437    1
#> [16,]     1.2  1   0   1  3.30672583    1
#> [17,]     1.2  1   0   1  2.09695409    1
#> [18,]     1.2  1   0   1  0.17264662    1
#> [19,]     1.2  1   0   1  4.24811757    1
#> [20,]     1.2  1   0   1  0.75938436    1
#> [21,]     1.2  1   0   0  0.10053118    1
#> [22,]     1.2  1   0   0  3.44641452    1
#> [23,]     1.2  1   0   0  1.56920613    1
#> [24,]     1.2  1   0   0  0.21288150    1
#> [25,]     1.2  1   0   0  2.84929736    1
#> [26,]     1.2  1   0   0  0.04649333    1
#> [27,]     1.2  1   0   0  3.82051145    1
#> [28,]     1.2  1   0   0  1.55021912    1
#> [29,]     1.2  1   0   0  0.70449877    1
#> [30,]     1.2  1   0   0  0.11130037    1
#> [31,]     1.2  1   1   0  6.43813924    1
#> [32,]     1.2  1   1   0  6.93079498    1
#> [33,]     1.2  1   1   0  0.99229093    1
#> [34,]     1.2  1   1   0  3.77863485    1
#> [35,]     1.2  1   1   0  0.34298551    1
#> [36,]     1.2  1   1   0  0.26177070    1
#> [37,]     1.2  1   1   0  0.02657705    1
#> [38,]     1.2  1   1   0  1.54165831    1
#> [39,]     1.2  1   1   0  2.64244702    1
#> [40,]     1.2  1   1   0  3.59785818    1
#> [41,]     1.2  1   1   0  0.23183945    1
#> [42,]     1.2  1   1   0  5.46339642    1
#> [43,]     1.2  1   1   0  0.52635326    1
#> [44,]     1.2  1   1   0  0.04060707    1
#> [45,]     1.2  1   1   0  1.99038120    1
#> [46,]     1.2  1   1   0  1.88077795    1
#> [47,]     1.2  1   1   0  4.22882856    1
#> [48,]     1.2  1   1   0  0.56096873    1
#> [49,]     1.2  1   1   0  0.74292159    1
#> [50,]     1.2  1   1   0  3.96033059    1
#> [51,]     1.2  1   1   0  1.45077668    1
#> [52,]     1.2  1   1   0  2.23572244    1
#> [53,]     1.2  1   1   0  1.40445460    1
#> [54,]     1.2  1   1   0  7.50148515    1
#> [55,]     1.2  1   1   0  6.15813485    1
#> [56,]     1.2  1   1   0  2.78753005    1
#> [57,]     1.2  1   1   0  0.13039679    1
#> [58,]     1.2  1   1   0  0.38887645    1
#> [59,]     1.2  1   1   0  0.08816548    1
#> [60,]     1.2  1   1   0  2.03881665    1
#> [61,]     1.2  1   1   0  2.79267993    1
#> [62,]     1.2  1   1   0  0.99544995    1
#> [63,]     1.2  1   1   0  0.13387519    1
#> [64,]     1.2  1   1   0  0.02126226    1
#> [65,]     1.2  1   1   0  3.64145746    1
#> [66,]     1.2  1   1   0  0.46699277    1
#> [67,]     1.2  1   1   0  0.67787167    1
#> [68,]     1.2  1   1   0  0.72450984    1
#> [69,]     1.2  1   1   0  1.90121290    1
#> [70,]     1.2  1   1   0  0.27688375    1
#> 
#> [[14]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]     1.2  1   0   1 1.234017608    1
#>  [2,]     1.2  1   0   1 0.227377951    1
#>  [3,]     1.2  1   0   1 0.696398899    1
#>  [4,]     1.2  1   0   1 0.967260559    1
#>  [5,]     1.2  1   0   1 2.611575654    1
#>  [6,]     1.2  1   0   1 3.678481730    1
#>  [7,]     1.2  1   0   1 1.929626135    1
#>  [8,]     1.2  1   0   1 1.578233170    1
#>  [9,]     1.2  1   0   1 3.921981994    1
#> [10,]     1.2  1   0   1 2.317277105    1
#> [11,]     1.2  1   0   1 1.900310157    1
#> [12,]     1.2  1   0   1 0.679701058    1
#> [13,]     1.2  1   0   1 1.675068375    1
#> [14,]     1.2  1   0   1 0.493782733    1
#> [15,]     1.2  1   0   1 0.708450534    1
#> [16,]     1.2  1   0   1 1.001547788    1
#> [17,]     1.2  1   0   1 0.547608735    1
#> [18,]     1.2  1   0   1 2.126862731    1
#> [19,]     1.2  1   0   1 0.142195281    1
#> [20,]     1.2  1   0   1 0.136512067    1
#> [21,]     1.2  1   0   0 2.881588747    1
#> [22,]     1.2  1   0   0 0.333852775    1
#> [23,]     1.2  1   0   0 2.132005948    1
#> [24,]     1.2  1   0   0 7.352788453    1
#> [25,]     1.2  1   0   0 3.035213460    1
#> [26,]     1.2  1   0   0 0.989410909    1
#> [27,]     1.2  1   0   0 5.138753060    1
#> [28,]     1.2  1   0   0 1.243584803    1
#> [29,]     1.2  1   0   0 0.585330660    1
#> [30,]     1.2  1   0   0 2.239375033    1
#> [31,]     1.2  1   1   0 3.035819046    1
#> [32,]     1.2  1   1   0 0.308193834    1
#> [33,]     1.2  1   1   0 0.192406779    1
#> [34,]     1.2  1   1   0 4.101677779    1
#> [35,]     1.2  1   1   0 3.893826332    1
#> [36,]     1.2  1   1   0 1.006908384    1
#> [37,]     1.2  1   1   0 1.124400448    1
#> [38,]     1.2  1   1   0 0.339290820    1
#> [39,]     1.2  1   1   0 0.313650616    1
#> [40,]     1.2  1   1   0 2.013649560    1
#> [41,]     1.2  1   1   0 3.767543383    1
#> [42,]     1.2  1   1   0 2.295009656    1
#> [43,]     1.2  1   1   0 1.195887423    1
#> [44,]     1.2  1   1   0 0.152417110    1
#> [45,]     1.2  1   1   0 2.557585148    1
#> [46,]     1.2  1   1   0 0.535491452    1
#> [47,]     1.2  1   1   0 3.210086051    1
#> [48,]     1.2  1   1   0 0.712880960    1
#> [49,]     1.2  1   1   0 0.224293722    1
#> [50,]     1.2  1   1   0 2.111654469    1
#> [51,]     1.2  1   1   0 2.733189961    1
#> [52,]     1.2  1   1   0 3.110376403    1
#> [53,]     1.2  1   1   0 0.054813908    1
#> [54,]     1.2  1   1   0 0.064013249    1
#> [55,]     1.2  1   1   0 2.430334281    1
#> [56,]     1.2  1   1   0 1.550367533    1
#> [57,]     1.2  1   1   0 2.981783867    1
#> [58,]     1.2  1   1   0 2.526475671    1
#> [59,]     1.2  1   1   0 0.133200707    1
#> [60,]     1.2  1   1   0 1.085319854    1
#> [61,]     1.2  1   1   0 4.799311895    1
#> [62,]     1.2  1   1   0 4.689876441    1
#> [63,]     1.2  1   1   0 0.801824099    1
#> [64,]     1.2  1   1   0 1.957815330    1
#> [65,]     1.2  1   1   0 0.312149804    1
#> [66,]     1.2  1   1   0 2.784711126    1
#> [67,]     1.2  1   1   0 2.060523985    1
#> [68,]     1.2  1   1   0 1.412926298    1
#> [69,]     1.2  1   1   0 0.008740116    1
#> [70,]     1.2  1   1   0 2.434424449    1
#> 
#> [[15]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]     1.2  1   0   1  0.13185355    1
#>  [2,]     1.2  1   0   1  4.94215109    1
#>  [3,]     1.2  1   0   1  1.15506130    1
#>  [4,]     1.2  1   0   1  5.47854940    1
#>  [5,]     1.2  1   0   1  2.09084361    1
#>  [6,]     1.2  1   0   1  7.84814409    1
#>  [7,]     1.2  1   0   1  2.27158087    1
#>  [8,]     1.2  1   0   1  0.39102322    1
#>  [9,]     1.2  1   0   1  0.62748246    1
#> [10,]     1.2  1   0   1  2.55417819    1
#> [11,]     1.2  1   0   1  1.51495003    1
#> [12,]     1.2  1   0   1  1.49979690    1
#> [13,]     1.2  1   0   1 10.91244454    1
#> [14,]     1.2  1   0   1  1.55865781    1
#> [15,]     1.2  1   0   1  0.38001982    1
#> [16,]     1.2  1   0   1  1.13465287    1
#> [17,]     1.2  1   0   1  0.07296316    1
#> [18,]     1.2  1   0   1  8.23632444    1
#> [19,]     1.2  1   0   1  4.53140850    1
#> [20,]     1.2  1   0   1  0.68062463    1
#> [21,]     1.2  1   0   0  0.72671253    1
#> [22,]     1.2  1   0   0  5.51525762    1
#> [23,]     1.2  1   0   0  3.63987636    1
#> [24,]     1.2  1   0   0  0.22138566    1
#> [25,]     1.2  1   0   0  0.18399619    1
#> [26,]     1.2  1   0   0  3.65037106    1
#> [27,]     1.2  1   0   0  0.15871211    1
#> [28,]     1.2  1   0   0  7.14225831    1
#> [29,]     1.2  1   0   0  0.92715583    1
#> [30,]     1.2  1   0   0  0.88579051    1
#> [31,]     1.2  1   1   0  0.15795637    1
#> [32,]     1.2  1   1   0  0.20834992    1
#> [33,]     1.2  1   1   0  0.77486112    1
#> [34,]     1.2  1   1   0  4.14439484    1
#> [35,]     1.2  1   1   0  4.13939520    1
#> [36,]     1.2  1   1   0  1.16437851    1
#> [37,]     1.2  1   1   0  2.43878900    1
#> [38,]     1.2  1   1   0  1.09269175    1
#> [39,]     1.2  1   1   0  1.97601801    1
#> [40,]     1.2  1   1   0  0.62451734    1
#> [41,]     1.2  1   1   0  0.23048532    1
#> [42,]     1.2  1   1   0  0.89513798    1
#> [43,]     1.2  1   1   0  0.64019447    1
#> [44,]     1.2  1   1   0  0.73264742    1
#> [45,]     1.2  1   1   0  0.80342395    1
#> [46,]     1.2  1   1   0  0.33765293    1
#> [47,]     1.2  1   1   0  2.50558439    1
#> [48,]     1.2  1   1   0  2.24320462    1
#> [49,]     1.2  1   1   0  3.45429180    1
#> [50,]     1.2  1   1   0  0.25494028    1
#> [51,]     1.2  1   1   0  1.30359013    1
#> [52,]     1.2  1   1   0  4.31742736    1
#> [53,]     1.2  1   1   0  0.20680400    1
#> [54,]     1.2  1   1   0  3.45693040    1
#> [55,]     1.2  1   1   0  0.55716756    1
#> [56,]     1.2  1   1   0  1.88907276    1
#> [57,]     1.2  1   1   0  0.84255286    1
#> [58,]     1.2  1   1   0  4.15977830    1
#> [59,]     1.2  1   1   0  3.62771444    1
#> [60,]     1.2  1   1   0  0.68628435    1
#> [61,]     1.2  1   1   0  0.68904146    1
#> [62,]     1.2  1   1   0  0.04092738    1
#> [63,]     1.2  1   1   0  8.33459625    1
#> [64,]     1.2  1   1   0  2.26774654    1
#> [65,]     1.2  1   1   0  1.13540121    1
#> [66,]     1.2  1   1   0  1.33399522    1
#> [67,]     1.2  1   1   0  1.31193687    1
#> [68,]     1.2  1   1   0  1.20556100    1
#> [69,]     1.2  1   1   0  1.18891331    1
#> [70,]     1.2  1   1   0  0.51620277    1
#> 
#> [[16]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]     1.2  1   0   1  0.30630164    1
#>  [2,]     1.2  1   0   1 10.74352846    1
#>  [3,]     1.2  1   0   1  5.80110706    1
#>  [4,]     1.2  1   0   1  0.50164800    1
#>  [5,]     1.2  1   0   1  2.39422816    1
#>  [6,]     1.2  1   0   1  0.19525664    1
#>  [7,]     1.2  1   0   1  6.30313748    1
#>  [8,]     1.2  1   0   1  1.60780321    1
#>  [9,]     1.2  1   0   1  2.50634777    1
#> [10,]     1.2  1   0   1  0.80368453    1
#> [11,]     1.2  1   0   1  3.93630942    1
#> [12,]     1.2  1   0   1  2.48203214    1
#> [13,]     1.2  1   0   1  6.12051613    0
#> [14,]     1.2  1   0   1  0.69471680    1
#> [15,]     1.2  1   0   1  0.92175101    1
#> [16,]     1.2  1   0   1  5.93885235    1
#> [17,]     1.2  1   0   1  2.44738248    1
#> [18,]     1.2  1   0   1  2.15878604    1
#> [19,]     1.2  1   0   1  0.85646294    1
#> [20,]     1.2  1   0   1  0.58675577    1
#> [21,]     1.2  1   0   0  1.43643192    1
#> [22,]     1.2  1   0   0  1.91402355    1
#> [23,]     1.2  1   0   0  0.81244372    1
#> [24,]     1.2  1   0   0  2.48585126    1
#> [25,]     1.2  1   0   0  1.59528084    1
#> [26,]     1.2  1   0   0  1.18990275    1
#> [27,]     1.2  1   0   0  0.46025858    1
#> [28,]     1.2  1   0   0  3.15649013    0
#> [29,]     1.2  1   0   0  3.94419198    1
#> [30,]     1.2  1   0   0  0.48305503    1
#> [31,]     1.2  1   1   0  1.39498438    1
#> [32,]     1.2  1   1   0 10.04156682    1
#> [33,]     1.2  1   1   0  1.55637881    1
#> [34,]     1.2  1   1   0  1.96650844    1
#> [35,]     1.2  1   1   0  1.53382047    1
#> [36,]     1.2  1   1   0  0.03937337    1
#> [37,]     1.2  1   1   0  0.54829270    1
#> [38,]     1.2  1   1   0  1.37252320    1
#> [39,]     1.2  1   1   0  0.45740807    1
#> [40,]     1.2  1   1   0  3.59267755    1
#> [41,]     1.2  1   1   0  0.64980338    1
#> [42,]     1.2  1   1   0  1.59387888    1
#> [43,]     1.2  1   1   0  0.42377296    1
#> [44,]     1.2  1   1   0  1.77885973    1
#> [45,]     1.2  1   1   0  2.44699475    1
#> [46,]     1.2  1   1   0  1.34462339    1
#> [47,]     1.2  1   1   0  0.93320294    1
#> [48,]     1.2  1   1   0  1.87226814    1
#> [49,]     1.2  1   1   0  0.61707336    1
#> [50,]     1.2  1   1   0  0.08862367    1
#> [51,]     1.2  1   1   0  0.69211787    1
#> [52,]     1.2  1   1   0  2.14709662    1
#> [53,]     1.2  1   1   0  3.74490970    1
#> [54,]     1.2  1   1   0  0.33931741    1
#> [55,]     1.2  1   1   0  0.83269220    1
#> [56,]     1.2  1   1   0  0.13018731    1
#> [57,]     1.2  1   1   0  0.18472636    0
#> [58,]     1.2  1   1   0  1.43251345    1
#> [59,]     1.2  1   1   0  2.10542597    1
#> [60,]     1.2  1   1   0  0.58879485    1
#> [61,]     1.2  1   1   0  2.31208201    1
#> [62,]     1.2  1   1   0  5.53203107    1
#> [63,]     1.2  1   1   0  0.82936579    1
#> [64,]     1.2  1   1   0  0.27849499    1
#> [65,]     1.2  1   1   0  0.57758994    1
#> [66,]     1.2  1   1   0  4.34245146    1
#> [67,]     1.2  1   1   0  0.83923040    1
#> [68,]     1.2  1   1   0  1.51627668    1
#> [69,]     1.2  1   1   0  2.06932661    1
#> [70,]     1.2  1   1   0  0.34050731    1
#> 
#> [[17]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]     1.2  1   0   1 0.47286163    1
#>  [2,]     1.2  1   0   1 1.01143013    1
#>  [3,]     1.2  1   0   1 2.29383917    1
#>  [4,]     1.2  1   0   1 0.97114493    1
#>  [5,]     1.2  1   0   1 0.42176978    1
#>  [6,]     1.2  1   0   1 0.02008101    1
#>  [7,]     1.2  1   0   1 3.35820856    1
#>  [8,]     1.2  1   0   1 2.17750976    1
#>  [9,]     1.2  1   0   1 5.77957809    1
#> [10,]     1.2  1   0   1 1.41586268    1
#> [11,]     1.2  1   0   1 0.36951521    1
#> [12,]     1.2  1   0   1 4.33824094    1
#> [13,]     1.2  1   0   1 0.17675465    1
#> [14,]     1.2  1   0   1 2.81305514    1
#> [15,]     1.2  1   0   1 1.51881245    1
#> [16,]     1.2  1   0   1 0.88295794    0
#> [17,]     1.2  1   0   1 4.60608127    1
#> [18,]     1.2  1   0   1 3.37525910    1
#> [19,]     1.2  1   0   1 0.73805692    1
#> [20,]     1.2  1   0   1 0.26874632    1
#> [21,]     1.2  1   0   0 2.10932697    1
#> [22,]     1.2  1   0   0 0.93688505    0
#> [23,]     1.2  1   0   0 2.94455045    1
#> [24,]     1.2  1   0   0 3.26795828    1
#> [25,]     1.2  1   0   0 7.46584604    1
#> [26,]     1.2  1   0   0 3.75088653    1
#> [27,]     1.2  1   0   0 6.37714899    1
#> [28,]     1.2  1   0   0 2.24816979    1
#> [29,]     1.2  1   0   0 2.35209598    1
#> [30,]     1.2  1   0   0 0.56309929    1
#> [31,]     1.2  1   1   0 0.36553974    1
#> [32,]     1.2  1   1   0 0.39037466    1
#> [33,]     1.2  1   1   0 0.95671991    1
#> [34,]     1.2  1   1   0 0.37453303    1
#> [35,]     1.2  1   1   0 5.80171074    1
#> [36,]     1.2  1   1   0 1.31310781    1
#> [37,]     1.2  1   1   0 0.72274846    1
#> [38,]     1.2  1   1   0 4.16281036    1
#> [39,]     1.2  1   1   0 0.22464451    1
#> [40,]     1.2  1   1   0 1.90594495    1
#> [41,]     1.2  1   1   0 1.64262813    1
#> [42,]     1.2  1   1   0 0.78013964    1
#> [43,]     1.2  1   1   0 1.29743251    1
#> [44,]     1.2  1   1   0 4.97110200    1
#> [45,]     1.2  1   1   0 2.74906027    1
#> [46,]     1.2  1   1   0 0.62002893    1
#> [47,]     1.2  1   1   0 5.14849268    1
#> [48,]     1.2  1   1   0 0.38886442    1
#> [49,]     1.2  1   1   0 0.91543644    1
#> [50,]     1.2  1   1   0 6.34270658    1
#> [51,]     1.2  1   1   0 2.43897782    1
#> [52,]     1.2  1   1   0 0.26251025    1
#> [53,]     1.2  1   1   0 2.04267346    1
#> [54,]     1.2  1   1   0 0.43859328    0
#> [55,]     1.2  1   1   0 5.04729756    1
#> [56,]     1.2  1   1   0 1.53541212    1
#> [57,]     1.2  1   1   0 2.57877708    1
#> [58,]     1.2  1   1   0 0.38382457    1
#> [59,]     1.2  1   1   0 2.70184361    1
#> [60,]     1.2  1   1   0 8.42731095    1
#> [61,]     1.2  1   1   0 0.03514814    1
#> [62,]     1.2  1   1   0 1.30897924    1
#> [63,]     1.2  1   1   0 1.79786566    1
#> [64,]     1.2  1   1   0 0.10850651    1
#> [65,]     1.2  1   1   0 0.66553032    1
#> [66,]     1.2  1   1   0 6.35390031    1
#> [67,]     1.2  1   1   0 0.56330896    0
#> [68,]     1.2  1   1   0 0.71571193    0
#> [69,]     1.2  1   1   0 0.64494728    1
#> [70,]     1.2  1   1   0 0.10407120    1
#> 
#> [[18]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]     1.2  1   0   1 2.49794089    1
#>  [2,]     1.2  1   0   1 0.92332866    1
#>  [3,]     1.2  1   0   1 6.44239002    1
#>  [4,]     1.2  1   0   1 2.37066504    1
#>  [5,]     1.2  1   0   1 6.59017292    1
#>  [6,]     1.2  1   0   1 3.82435185    1
#>  [7,]     1.2  1   0   1 0.94892432    1
#>  [8,]     1.2  1   0   1 0.63699843    1
#>  [9,]     1.2  1   0   1 0.99176004    1
#> [10,]     1.2  1   0   1 3.76813438    1
#> [11,]     1.2  1   0   1 1.03000410    1
#> [12,]     1.2  1   0   1 1.94586499    1
#> [13,]     1.2  1   0   1 8.04804162    1
#> [14,]     1.2  1   0   1 0.60949010    1
#> [15,]     1.2  1   0   1 4.83486953    1
#> [16,]     1.2  1   0   1 2.73126415    1
#> [17,]     1.2  1   0   1 0.72236549    1
#> [18,]     1.2  1   0   1 0.05075747    1
#> [19,]     1.2  1   0   1 5.27231334    1
#> [20,]     1.2  1   0   1 1.44111469    1
#> [21,]     1.2  1   0   0 5.24529548    1
#> [22,]     1.2  1   0   0 1.59476036    1
#> [23,]     1.2  1   0   0 1.21048976    1
#> [24,]     1.2  1   0   0 1.87139255    1
#> [25,]     1.2  1   0   0 0.02181253    1
#> [26,]     1.2  1   0   0 0.43767655    1
#> [27,]     1.2  1   0   0 0.08427198    1
#> [28,]     1.2  1   0   0 0.61137768    1
#> [29,]     1.2  1   0   0 5.06978832    1
#> [30,]     1.2  1   0   0 5.70650215    1
#> [31,]     1.2  1   1   0 6.39939502    1
#> [32,]     1.2  1   1   0 5.47788889    1
#> [33,]     1.2  1   1   0 4.40666631    1
#> [34,]     1.2  1   1   0 3.27282326    1
#> [35,]     1.2  1   1   0 1.51315754    1
#> [36,]     1.2  1   1   0 3.91509623    1
#> [37,]     1.2  1   1   0 2.15619477    1
#> [38,]     1.2  1   1   0 0.82283312    1
#> [39,]     1.2  1   1   0 1.20360818    1
#> [40,]     1.2  1   1   0 3.21583810    1
#> [41,]     1.2  1   1   0 2.61646124    1
#> [42,]     1.2  1   1   0 5.52867169    1
#> [43,]     1.2  1   1   0 1.20434987    1
#> [44,]     1.2  1   1   0 0.25463059    1
#> [45,]     1.2  1   1   0 5.87184429    1
#> [46,]     1.2  1   1   0 5.12837230    1
#> [47,]     1.2  1   1   0 1.97660995    1
#> [48,]     1.2  1   1   0 2.83364718    1
#> [49,]     1.2  1   1   0 0.91053865    1
#> [50,]     1.2  1   1   0 0.15945389    1
#> [51,]     1.2  1   1   0 0.18351206    1
#> [52,]     1.2  1   1   0 0.55779477    1
#> [53,]     1.2  1   1   0 2.58968455    1
#> [54,]     1.2  1   1   0 2.86063481    1
#> [55,]     1.2  1   1   0 0.25258703    1
#> [56,]     1.2  1   1   0 4.91793178    1
#> [57,]     1.2  1   1   0 2.03646130    1
#> [58,]     1.2  1   1   0 0.32708133    1
#> [59,]     1.2  1   1   0 0.77863582    1
#> [60,]     1.2  1   1   0 0.55499615    1
#> [61,]     1.2  1   1   0 0.95050076    1
#> [62,]     1.2  1   1   0 2.57888561    1
#> [63,]     1.2  1   1   0 5.24303995    1
#> [64,]     1.2  1   1   0 0.51952497    1
#> [65,]     1.2  1   1   0 1.06219158    1
#> [66,]     1.2  1   1   0 3.30130843    1
#> [67,]     1.2  1   1   0 0.90828412    1
#> [68,]     1.2  1   1   0 3.69895912    1
#> [69,]     1.2  1   1   0 2.18341126    1
#> [70,]     1.2  1   1   0 1.84567084    1
#> 
#> [[19]]
#>       driftHR HR ext trt         time cnsr
#>  [1,]     1.2  1   0   1  0.003894115    1
#>  [2,]     1.2  1   0   1  1.369593448    1
#>  [3,]     1.2  1   0   1  0.265326113    1
#>  [4,]     1.2  1   0   1  7.506083920    1
#>  [5,]     1.2  1   0   1  1.176684950    1
#>  [6,]     1.2  1   0   1  0.558157485    1
#>  [7,]     1.2  1   0   1  0.135893614    1
#>  [8,]     1.2  1   0   1  1.635726258    1
#>  [9,]     1.2  1   0   1  5.279840346    1
#> [10,]     1.2  1   0   1  2.083634097    1
#> [11,]     1.2  1   0   1  2.793712284    1
#> [12,]     1.2  1   0   1  4.121060561    1
#> [13,]     1.2  1   0   1  4.658970859    1
#> [14,]     1.2  1   0   1  4.485939171    1
#> [15,]     1.2  1   0   1  1.180082088    1
#> [16,]     1.2  1   0   1  0.255527509    1
#> [17,]     1.2  1   0   1  1.421739016    1
#> [18,]     1.2  1   0   1  0.896959190    1
#> [19,]     1.2  1   0   1  1.994320227    1
#> [20,]     1.2  1   0   1  0.301615145    1
#> [21,]     1.2  1   0   0  1.003879110    1
#> [22,]     1.2  1   0   0  0.011838630    1
#> [23,]     1.2  1   0   0  0.463854630    1
#> [24,]     1.2  1   0   0  3.109603077    1
#> [25,]     1.2  1   0   0  1.599345779    1
#> [26,]     1.2  1   0   0  2.460695384    1
#> [27,]     1.2  1   0   0  0.896751343    1
#> [28,]     1.2  1   0   0  1.386085509    1
#> [29,]     1.2  1   0   0  0.283094238    1
#> [30,]     1.2  1   0   0  1.988404931    1
#> [31,]     1.2  1   1   0  1.132794380    1
#> [32,]     1.2  1   1   0  2.743204558    1
#> [33,]     1.2  1   1   0 12.956167664    1
#> [34,]     1.2  1   1   0  0.039495081    1
#> [35,]     1.2  1   1   0  1.035354757    1
#> [36,]     1.2  1   1   0  1.274851836    1
#> [37,]     1.2  1   1   0  0.833599199    1
#> [38,]     1.2  1   1   0  0.527382674    1
#> [39,]     1.2  1   1   0  2.280693884    1
#> [40,]     1.2  1   1   0  0.930310695    1
#> [41,]     1.2  1   1   0  1.465205440    1
#> [42,]     1.2  1   1   0  0.573415873    1
#> [43,]     1.2  1   1   0  3.478057537    1
#> [44,]     1.2  1   1   0  2.947179701    1
#> [45,]     1.2  1   1   0  1.511181123    1
#> [46,]     1.2  1   1   0  6.317942457    1
#> [47,]     1.2  1   1   0  3.002703857    1
#> [48,]     1.2  1   1   0  1.017974286    1
#> [49,]     1.2  1   1   0  2.456621203    1
#> [50,]     1.2  1   1   0  1.517251870    1
#> [51,]     1.2  1   1   0  0.471410239    1
#> [52,]     1.2  1   1   0  5.350126918    1
#> [53,]     1.2  1   1   0  5.500810813    1
#> [54,]     1.2  1   1   0  2.319902107    1
#> [55,]     1.2  1   1   0  0.944716110    1
#> [56,]     1.2  1   1   0  6.438875839    1
#> [57,]     1.2  1   1   0  1.233168621    1
#> [58,]     1.2  1   1   0  0.171860023    1
#> [59,]     1.2  1   1   0  3.155711517    1
#> [60,]     1.2  1   1   0  0.187041570    1
#> [61,]     1.2  1   1   0  2.839501645    1
#> [62,]     1.2  1   1   0  2.700353784    1
#> [63,]     1.2  1   1   0  0.265633440    1
#> [64,]     1.2  1   1   0  0.523931403    1
#> [65,]     1.2  1   1   0  3.236016958    1
#> [66,]     1.2  1   1   0  1.403067324    1
#> [67,]     1.2  1   1   0  3.202382192    1
#> [68,]     1.2  1   1   0  0.092400293    1
#> [69,]     1.2  1   1   0  0.514977469    1
#> [70,]     1.2  1   1   0  0.558712573    1
#> 
#> [[20]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]     1.2  1   0   1  1.43568168    1
#>  [2,]     1.2  1   0   1  0.30164070    1
#>  [3,]     1.2  1   0   1  3.25689663    1
#>  [4,]     1.2  1   0   1  2.70693750    1
#>  [5,]     1.2  1   0   1  8.18462322    1
#>  [6,]     1.2  1   0   1  2.63165568    1
#>  [7,]     1.2  1   0   1  0.29696231    1
#>  [8,]     1.2  1   0   1  0.05380828    1
#>  [9,]     1.2  1   0   1  0.46948765    1
#> [10,]     1.2  1   0   1  0.38762770    1
#> [11,]     1.2  1   0   1  2.18551242    0
#> [12,]     1.2  1   0   1  3.12131378    1
#> [13,]     1.2  1   0   1  0.39138588    1
#> [14,]     1.2  1   0   1  1.79050687    1
#> [15,]     1.2  1   0   1  4.39956883    1
#> [16,]     1.2  1   0   1  2.79781561    1
#> [17,]     1.2  1   0   1  0.18388758    1
#> [18,]     1.2  1   0   1  4.05021992    1
#> [19,]     1.2  1   0   1  1.49330656    1
#> [20,]     1.2  1   0   1  3.25002882    1
#> [21,]     1.2  1   0   0  0.13433806    1
#> [22,]     1.2  1   0   0  0.04832941    1
#> [23,]     1.2  1   0   0  1.26434498    1
#> [24,]     1.2  1   0   0  0.82212872    1
#> [25,]     1.2  1   0   0  0.82245888    1
#> [26,]     1.2  1   0   0  5.03997794    1
#> [27,]     1.2  1   0   0  1.22297936    1
#> [28,]     1.2  1   0   0  0.61094305    1
#> [29,]     1.2  1   0   0  0.65175966    1
#> [30,]     1.2  1   0   0  1.69379994    1
#> [31,]     1.2  1   1   0  0.54752338    1
#> [32,]     1.2  1   1   0  0.59571615    1
#> [33,]     1.2  1   1   0  0.05473361    0
#> [34,]     1.2  1   1   0  0.41010248    1
#> [35,]     1.2  1   1   0  8.15341545    1
#> [36,]     1.2  1   1   0  0.22149882    1
#> [37,]     1.2  1   1   0  6.15876549    0
#> [38,]     1.2  1   1   0  2.89181772    1
#> [39,]     1.2  1   1   0 10.02523592    1
#> [40,]     1.2  1   1   0  1.34122858    1
#> [41,]     1.2  1   1   0  1.08694965    1
#> [42,]     1.2  1   1   0  4.05671004    1
#> [43,]     1.2  1   1   0  1.10911893    1
#> [44,]     1.2  1   1   0  0.39888315    1
#> [45,]     1.2  1   1   0  0.46090098    1
#> [46,]     1.2  1   1   0  9.98820171    1
#> [47,]     1.2  1   1   0  2.84491890    1
#> [48,]     1.2  1   1   0  1.06898423    1
#> [49,]     1.2  1   1   0  1.61550487    1
#> [50,]     1.2  1   1   0 11.05368874    1
#> [51,]     1.2  1   1   0  3.95600069    1
#> [52,]     1.2  1   1   0  0.56241849    0
#> [53,]     1.2  1   1   0  2.13645755    1
#> [54,]     1.2  1   1   0  3.51496873    1
#> [55,]     1.2  1   1   0  1.51224524    1
#> [56,]     1.2  1   1   0  0.89552051    1
#> [57,]     1.2  1   1   0  2.62566246    1
#> [58,]     1.2  1   1   0  7.50713339    1
#> [59,]     1.2  1   1   0  1.48534162    1
#> [60,]     1.2  1   1   0  0.56345845    1
#> [61,]     1.2  1   1   0  0.84361780    1
#> [62,]     1.2  1   1   0  4.15050352    1
#> [63,]     1.2  1   1   0  0.13692175    1
#> [64,]     1.2  1   1   0  1.18295621    1
#> [65,]     1.2  1   1   0  0.76995111    1
#> [66,]     1.2  1   1   0  0.75291151    1
#> [67,]     1.2  1   1   0  1.15598940    1
#> [68,]     1.2  1   1   0  1.42434179    1
#> [69,]     1.2  1   1   0  7.33680519    1
#> [70,]     1.2  1   1   0  3.34623694    1
#> 

# simulate time-to-event with an exponential distribution
evt2 <- set_event(event = "pwexp", t_itv = 1, lambdaC = c(0.1, 0.02))
simu_time(dt = sample_hr, eventObj = evt2, clinInt = c_int, clinExt = c_int)
#> Simulating survival time... Set seed to 10403
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> All original covariates (if any):  are used for time-to-failure.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> 0 patients enrolled after 64 days after the study started were excluded from the analysis.
#> Simulated time are not saved.
#> [[1]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]       1  1   0   1 0.42621708    1
#>  [2,]       1  1   0   1 0.20327137    1
#>  [3,]       1  1   0   1 0.76510740    1
#>  [4,]       1  1   0   1 1.47800753    1
#>  [5,]       1  1   0   1 0.27180720    0
#>  [6,]       1  1   0   1 2.20217909    1
#>  [7,]       1  1   0   1 1.26180764    1
#>  [8,]       1  1   0   1 0.21403642    1
#>  [9,]       1  1   0   1 1.07284658    1
#> [10,]       1  1   0   1 3.20200827    1
#> [11,]       1  1   0   1 2.01111879    1
#> [12,]       1  1   0   1 0.36779027    1
#> [13,]       1  1   0   1 3.08097828    1
#> [14,]       1  1   0   1 1.48885010    1
#> [15,]       1  1   0   1 1.13563982    1
#> [16,]       1  1   0   1 2.72241378    1
#> [17,]       1  1   0   1 3.08692825    1
#> [18,]       1  1   0   1 0.77080486    1
#> [19,]       1  1   0   1 1.10960255    1
#> [20,]       1  1   0   1 1.25781155    1
#> [21,]       1  1   0   0 1.62020223    0
#> [22,]       1  1   0   0 0.90216489    1
#> [23,]       1  1   0   0 0.69315217    1
#> [24,]       1  1   0   0 0.74194452    1
#> [25,]       1  1   0   0 0.81711396    1
#> [26,]       1  1   0   0 3.86088919    1
#> [27,]       1  1   0   0 3.03508886    1
#> [28,]       1  1   0   0 5.00518739    1
#> [29,]       1  1   0   0 0.85858262    1
#> [30,]       1  1   0   0 0.72458868    1
#> [31,]       1  1   1   0 1.91778940    1
#> [32,]       1  1   1   0 3.92917768    1
#> [33,]       1  1   1   0 1.21334039    1
#> [34,]       1  1   1   0 0.29001425    1
#> [35,]       1  1   1   0 0.16158761    1
#> [36,]       1  1   1   0 2.64792514    1
#> [37,]       1  1   1   0 1.93324011    1
#> [38,]       1  1   1   0 1.72777975    1
#> [39,]       1  1   1   0 0.97550973    1
#> [40,]       1  1   1   0 2.81024423    1
#> [41,]       1  1   1   0 0.41952173    0
#> [42,]       1  1   1   0 1.84028575    1
#> [43,]       1  1   1   0 0.29521224    1
#> [44,]       1  1   1   0 1.36336632    1
#> [45,]       1  1   1   0 0.39320264    1
#> [46,]       1  1   1   0 0.05574666    1
#> [47,]       1  1   1   0 1.85419959    1
#> [48,]       1  1   1   0 0.66814840    1
#> [49,]       1  1   1   0 0.17073340    1
#> [50,]       1  1   1   0 0.51357995    1
#> [51,]       1  1   1   0 0.33335765    1
#> [52,]       1  1   1   0 1.71382804    1
#> [53,]       1  1   1   0 0.21339934    1
#> [54,]       1  1   1   0 0.98143092    1
#> [55,]       1  1   1   0 1.89495616    0
#> [56,]       1  1   1   0 1.76195599    1
#> [57,]       1  1   1   0 0.26088725    0
#> [58,]       1  1   1   0 1.21612556    1
#> [59,]       1  1   1   0 1.14000981    1
#> [60,]       1  1   1   0 0.79991225    1
#> [61,]       1  1   1   0 2.21426589    1
#> [62,]       1  1   1   0 2.33906643    1
#> [63,]       1  1   1   0 0.26310912    1
#> [64,]       1  1   1   0 0.21624858    1
#> [65,]       1  1   1   0 3.82141992    1
#> [66,]       1  1   1   0 0.92370168    1
#> [67,]       1  1   1   0 1.01590151    1
#> [68,]       1  1   1   0 0.89208337    1
#> [69,]       1  1   1   0 4.04844123    1
#> [70,]       1  1   1   0 1.28605588    1
#> 
#> [[2]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]       1  1   0   1 1.88524982    1
#>  [2,]       1  1   0   1 0.75878128    1
#>  [3,]       1  1   0   1 1.19093715    1
#>  [4,]       1  1   0   1 0.29800566    0
#>  [5,]       1  1   0   1 1.45003193    1
#>  [6,]       1  1   0   1 2.44290586    1
#>  [7,]       1  1   0   1 1.92413770    1
#>  [8,]       1  1   0   1 3.79647160    1
#>  [9,]       1  1   0   1 1.25324034    1
#> [10,]       1  1   0   1 0.19355522    1
#> [11,]       1  1   0   1 0.48141858    1
#> [12,]       1  1   0   1 4.26121115    1
#> [13,]       1  1   0   1 2.05162474    1
#> [14,]       1  1   0   1 2.93066217    1
#> [15,]       1  1   0   1 0.58530882    1
#> [16,]       1  1   0   1 1.86020741    1
#> [17,]       1  1   0   1 0.30955335    1
#> [18,]       1  1   0   1 2.31913430    1
#> [19,]       1  1   0   1 0.56777192    1
#> [20,]       1  1   0   1 1.63300160    1
#> [21,]       1  1   0   0 2.48362361    1
#> [22,]       1  1   0   0 1.05665822    1
#> [23,]       1  1   0   0 0.42243104    1
#> [24,]       1  1   0   0 0.17411967    1
#> [25,]       1  1   0   0 0.72022932    1
#> [26,]       1  1   0   0 0.16086303    1
#> [27,]       1  1   0   0 5.74435928    1
#> [28,]       1  1   0   0 1.56456288    1
#> [29,]       1  1   0   0 0.49952444    1
#> [30,]       1  1   0   0 1.08877101    1
#> [31,]       1  1   1   0 0.69679293    0
#> [32,]       1  1   1   0 0.20682064    0
#> [33,]       1  1   1   0 0.78427150    1
#> [34,]       1  1   1   0 8.33846889    1
#> [35,]       1  1   1   0 0.48062885    1
#> [36,]       1  1   1   0 0.76384561    1
#> [37,]       1  1   1   0 4.23471681    1
#> [38,]       1  1   1   0 2.50373726    1
#> [39,]       1  1   1   0 1.80756786    1
#> [40,]       1  1   1   0 3.05676587    1
#> [41,]       1  1   1   0 4.00987931    1
#> [42,]       1  1   1   0 0.36597085    0
#> [43,]       1  1   1   0 2.33347494    1
#> [44,]       1  1   1   0 0.03483033    0
#> [45,]       1  1   1   0 1.03531584    1
#> [46,]       1  1   1   0 1.28845742    1
#> [47,]       1  1   1   0 0.39047873    1
#> [48,]       1  1   1   0 1.32842322    1
#> [49,]       1  1   1   0 0.32175788    0
#> [50,]       1  1   1   0 2.11467320    1
#> [51,]       1  1   1   0 0.19079799    1
#> [52,]       1  1   1   0 1.71185345    0
#> [53,]       1  1   1   0 1.84833318    1
#> [54,]       1  1   1   0 2.21429091    1
#> [55,]       1  1   1   0 2.23972791    1
#> [56,]       1  1   1   0 2.48585056    1
#> [57,]       1  1   1   0 0.27722039    1
#> [58,]       1  1   1   0 0.51960822    1
#> [59,]       1  1   1   0 4.50199995    1
#> [60,]       1  1   1   0 4.77726722    1
#> [61,]       1  1   1   0 3.41504336    1
#> [62,]       1  1   1   0 2.01252142    1
#> [63,]       1  1   1   0 0.11084764    0
#> [64,]       1  1   1   0 0.78680509    0
#> [65,]       1  1   1   0 0.34396205    0
#> [66,]       1  1   1   0 2.36942788    1
#> [67,]       1  1   1   0 0.55250267    1
#> [68,]       1  1   1   0 0.18962834    1
#> [69,]       1  1   1   0 5.00551904    1
#> [70,]       1  1   1   0 3.16008084    1
#> 
#> [[3]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]       1  1   0   1 3.42884844    1
#>  [2,]       1  1   0   1 0.10946660    1
#>  [3,]       1  1   0   1 0.05390609    1
#>  [4,]       1  1   0   1 0.21047001    1
#>  [5,]       1  1   0   1 0.32307241    1
#>  [6,]       1  1   0   1 5.32701052    1
#>  [7,]       1  1   0   1 1.61195159    1
#>  [8,]       1  1   0   1 1.08997979    1
#>  [9,]       1  1   0   1 1.38703991    1
#> [10,]       1  1   0   1 0.70892727    0
#> [11,]       1  1   0   1 0.12249194    0
#> [12,]       1  1   0   1 0.78032755    1
#> [13,]       1  1   0   1 1.77541847    1
#> [14,]       1  1   0   1 4.73824111    1
#> [15,]       1  1   0   1 2.82009108    1
#> [16,]       1  1   0   1 3.98550216    1
#> [17,]       1  1   0   1 2.80808912    1
#> [18,]       1  1   0   1 3.28574907    1
#> [19,]       1  1   0   1 1.74121866    0
#> [20,]       1  1   0   1 0.85238004    1
#> [21,]       1  1   0   0 1.28735675    1
#> [22,]       1  1   0   0 0.20959948    1
#> [23,]       1  1   0   0 0.68622199    1
#> [24,]       1  1   0   0 0.01978041    1
#> [25,]       1  1   0   0 3.03215263    1
#> [26,]       1  1   0   0 1.01844529    1
#> [27,]       1  1   0   0 0.48696997    1
#> [28,]       1  1   0   0 0.20466892    1
#> [29,]       1  1   0   0 1.84610417    1
#> [30,]       1  1   0   0 1.22805588    1
#> [31,]       1  1   1   0 0.36561086    1
#> [32,]       1  1   1   0 2.32816891    1
#> [33,]       1  1   1   0 2.41112046    1
#> [34,]       1  1   1   0 0.37279583    1
#> [35,]       1  1   1   0 0.03261730    1
#> [36,]       1  1   1   0 1.40900753    1
#> [37,]       1  1   1   0 5.26004438    1
#> [38,]       1  1   1   0 0.06887495    1
#> [39,]       1  1   1   0 0.85303167    1
#> [40,]       1  1   1   0 2.12248735    1
#> [41,]       1  1   1   0 2.42285157    1
#> [42,]       1  1   1   0 0.56947593    1
#> [43,]       1  1   1   0 3.26444383    1
#> [44,]       1  1   1   0 1.21148110    1
#> [45,]       1  1   1   0 4.21574215    1
#> [46,]       1  1   1   0 0.73125917    1
#> [47,]       1  1   1   0 0.59945101    1
#> [48,]       1  1   1   0 0.01902537    1
#> [49,]       1  1   1   0 0.30309474    1
#> [50,]       1  1   1   0 4.15637324    1
#> [51,]       1  1   1   0 0.41948226    0
#> [52,]       1  1   1   0 0.22447985    1
#> [53,]       1  1   1   0 3.12378977    1
#> [54,]       1  1   1   0 3.48848170    1
#> [55,]       1  1   1   0 0.63683061    1
#> [56,]       1  1   1   0 1.89087986    1
#> [57,]       1  1   1   0 2.93488704    1
#> [58,]       1  1   1   0 0.43829110    1
#> [59,]       1  1   1   0 2.89787598    1
#> [60,]       1  1   1   0 0.89311351    1
#> [61,]       1  1   1   0 1.60052290    1
#> [62,]       1  1   1   0 2.38085804    1
#> [63,]       1  1   1   0 0.65941736    1
#> [64,]       1  1   1   0 1.56079078    1
#> [65,]       1  1   1   0 3.44795123    1
#> [66,]       1  1   1   0 0.32062766    1
#> [67,]       1  1   1   0 2.71099594    1
#> [68,]       1  1   1   0 2.28505029    1
#> [69,]       1  1   1   0 1.14245505    0
#> [70,]       1  1   1   0 0.98428185    1
#> 
#> [[4]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]       1  1   0   1 0.87361935    1
#>  [2,]       1  1   0   1 0.19594774    1
#>  [3,]       1  1   0   1 0.07125473    1
#>  [4,]       1  1   0   1 3.07215099    1
#>  [5,]       1  1   0   1 0.46486073    1
#>  [6,]       1  1   0   1 2.64519371    1
#>  [7,]       1  1   0   1 0.23523565    1
#>  [8,]       1  1   0   1 0.14172391    0
#>  [9,]       1  1   0   1 4.17655441    1
#> [10,]       1  1   0   1 0.57629990    1
#> [11,]       1  1   0   1 3.04777751    1
#> [12,]       1  1   0   1 1.92327224    1
#> [13,]       1  1   0   1 3.03278368    1
#> [14,]       1  1   0   1 3.83527072    1
#> [15,]       1  1   0   1 0.37730283    1
#> [16,]       1  1   0   1 0.03154725    0
#> [17,]       1  1   0   1 0.62827618    1
#> [18,]       1  1   0   1 1.03819162    1
#> [19,]       1  1   0   1 0.48718466    0
#> [20,]       1  1   0   1 1.73424241    1
#> [21,]       1  1   0   0 2.59034012    1
#> [22,]       1  1   0   0 1.92218203    1
#> [23,]       1  1   0   0 1.04563931    1
#> [24,]       1  1   0   0 5.41088371    1
#> [25,]       1  1   0   0 3.17754556    1
#> [26,]       1  1   0   0 3.77123159    1
#> [27,]       1  1   0   0 4.30849807    0
#> [28,]       1  1   0   0 1.41479805    1
#> [29,]       1  1   0   0 1.30634925    1
#> [30,]       1  1   0   0 6.62049575    1
#> [31,]       1  1   1   0 0.04427730    1
#> [32,]       1  1   1   0 4.67978498    1
#> [33,]       1  1   1   0 1.20307374    1
#> [34,]       1  1   1   0 0.73086419    1
#> [35,]       1  1   1   0 2.44395526    1
#> [36,]       1  1   1   0 6.22868179    1
#> [37,]       1  1   1   0 0.08664672    1
#> [38,]       1  1   1   0 5.00904966    1
#> [39,]       1  1   1   0 0.82994346    1
#> [40,]       1  1   1   0 3.07297488    1
#> [41,]       1  1   1   0 0.57711786    1
#> [42,]       1  1   1   0 0.39531106    1
#> [43,]       1  1   1   0 0.93918857    1
#> [44,]       1  1   1   0 0.77196898    1
#> [45,]       1  1   1   0 1.97903141    1
#> [46,]       1  1   1   0 0.12919708    1
#> [47,]       1  1   1   0 0.40842619    1
#> [48,]       1  1   1   0 1.02847886    1
#> [49,]       1  1   1   0 0.44266957    1
#> [50,]       1  1   1   0 2.42524929    1
#> [51,]       1  1   1   0 4.25800686    1
#> [52,]       1  1   1   0 0.28688830    1
#> [53,]       1  1   1   0 0.27949073    1
#> [54,]       1  1   1   0 7.10274873    1
#> [55,]       1  1   1   0 2.09503298    1
#> [56,]       1  1   1   0 0.08546779    1
#> [57,]       1  1   1   0 3.73809472    1
#> [58,]       1  1   1   0 1.60231680    1
#> [59,]       1  1   1   0 1.36446461    1
#> [60,]       1  1   1   0 1.94285095    1
#> [61,]       1  1   1   0 1.25233273    1
#> [62,]       1  1   1   0 0.23806514    1
#> [63,]       1  1   1   0 0.07419464    0
#> [64,]       1  1   1   0 2.84852052    1
#> [65,]       1  1   1   0 0.52469446    1
#> [66,]       1  1   1   0 1.42852719    1
#> [67,]       1  1   1   0 0.95144412    1
#> [68,]       1  1   1   0 0.41056766    1
#> [69,]       1  1   1   0 0.87147319    1
#> [70,]       1  1   1   0 1.49040077    1
#> 
#> [[5]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]       1  1   0   1 3.190198890    1
#>  [2,]       1  1   0   1 2.105362451    1
#>  [3,]       1  1   0   1 0.842879537    1
#>  [4,]       1  1   0   1 0.966618961    1
#>  [5,]       1  1   0   1 0.679107573    1
#>  [6,]       1  1   0   1 0.166956182    1
#>  [7,]       1  1   0   1 1.304936470    1
#>  [8,]       1  1   0   1 6.409903228    1
#>  [9,]       1  1   0   1 3.165535465    1
#> [10,]       1  1   0   1 1.409359375    1
#> [11,]       1  1   0   1 2.514182260    1
#> [12,]       1  1   0   1 0.135701674    1
#> [13,]       1  1   0   1 1.538548366    1
#> [14,]       1  1   0   1 2.968872636    1
#> [15,]       1  1   0   1 0.806327371    1
#> [16,]       1  1   0   1 0.791987978    0
#> [17,]       1  1   0   1 0.495047260    1
#> [18,]       1  1   0   1 0.960165475    1
#> [19,]       1  1   0   1 5.099609816    1
#> [20,]       1  1   0   1 1.359207617    1
#> [21,]       1  1   0   0 0.851506772    0
#> [22,]       1  1   0   0 0.028272292    1
#> [23,]       1  1   0   0 0.095911368    1
#> [24,]       1  1   0   0 2.100908950    1
#> [25,]       1  1   0   0 0.788750183    0
#> [26,]       1  1   0   0 3.756838914    1
#> [27,]       1  1   0   0 2.924038504    1
#> [28,]       1  1   0   0 0.042826136    1
#> [29,]       1  1   0   0 0.466792102    1
#> [30,]       1  1   0   0 7.042904650    1
#> [31,]       1  1   1   0 0.575801163    0
#> [32,]       1  1   1   0 0.967132282    0
#> [33,]       1  1   1   0 1.634650987    1
#> [34,]       1  1   1   0 1.401997313    1
#> [35,]       1  1   1   0 1.310685677    1
#> [36,]       1  1   1   0 1.414637109    1
#> [37,]       1  1   1   0 9.772576186    1
#> [38,]       1  1   1   0 2.603141286    1
#> [39,]       1  1   1   0 0.077970692    1
#> [40,]       1  1   1   0 1.240246498    1
#> [41,]       1  1   1   0 0.967900472    1
#> [42,]       1  1   1   0 0.088113688    1
#> [43,]       1  1   1   0 0.705285065    1
#> [44,]       1  1   1   0 5.796361839    1
#> [45,]       1  1   1   0 0.041117949    1
#> [46,]       1  1   1   0 0.092455192    1
#> [47,]       1  1   1   0 4.882174452    1
#> [48,]       1  1   1   0 5.909805552    1
#> [49,]       1  1   1   0 0.376406856    1
#> [50,]       1  1   1   0 3.707973089    1
#> [51,]       1  1   1   0 2.716748474    1
#> [52,]       1  1   1   0 2.364265889    1
#> [53,]       1  1   1   0 0.007345753    1
#> [54,]       1  1   1   0 2.368076268    1
#> [55,]       1  1   1   0 0.796557827    1
#> [56,]       1  1   1   0 0.369393484    1
#> [57,]       1  1   1   0 0.079970917    1
#> [58,]       1  1   1   0 1.410858222    1
#> [59,]       1  1   1   0 2.351428259    1
#> [60,]       1  1   1   0 1.926966721    1
#> [61,]       1  1   1   0 5.988513772    1
#> [62,]       1  1   1   0 1.602726377    1
#> [63,]       1  1   1   0 0.952786488    1
#> [64,]       1  1   1   0 6.926344365    1
#> [65,]       1  1   1   0 1.269942570    1
#> [66,]       1  1   1   0 0.024702415    1
#> [67,]       1  1   1   0 0.445463406    0
#> [68,]       1  1   1   0 0.121454597    0
#> [69,]       1  1   1   0 1.373072913    1
#> [70,]       1  1   1   0 1.129349637    1
#> 
#> [[6]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]       1  1   0   1 0.27401397    1
#>  [2,]       1  1   0   1 0.35238971    1
#>  [3,]       1  1   0   1 1.59349807    1
#>  [4,]       1  1   0   1 4.58992248    1
#>  [5,]       1  1   0   1 1.26301208    1
#>  [6,]       1  1   0   1 3.63694291    1
#>  [7,]       1  1   0   1 6.50903358    1
#>  [8,]       1  1   0   1 2.10872014    1
#>  [9,]       1  1   0   1 0.18792149    1
#> [10,]       1  1   0   1 0.16834126    1
#> [11,]       1  1   0   1 1.74470857    1
#> [12,]       1  1   0   1 0.20528737    1
#> [13,]       1  1   0   1 1.01479593    1
#> [14,]       1  1   0   1 1.77030621    1
#> [15,]       1  1   0   1 3.09028442    1
#> [16,]       1  1   0   1 0.13800159    1
#> [17,]       1  1   0   1 1.12193107    1
#> [18,]       1  1   0   1 0.38666619    0
#> [19,]       1  1   0   1 1.67210582    1
#> [20,]       1  1   0   1 1.60402395    1
#> [21,]       1  1   0   0 2.49911146    1
#> [22,]       1  1   0   0 2.21995055    1
#> [23,]       1  1   0   0 0.83522551    1
#> [24,]       1  1   0   0 3.17615875    1
#> [25,]       1  1   0   0 1.78539380    1
#> [26,]       1  1   0   0 1.06842219    1
#> [27,]       1  1   0   0 3.88527437    1
#> [28,]       1  1   0   0 4.38535030    1
#> [29,]       1  1   0   0 0.47921267    1
#> [30,]       1  1   0   0 1.96732295    1
#> [31,]       1  1   1   0 0.84680191    1
#> [32,]       1  1   1   0 2.69563181    1
#> [33,]       1  1   1   0 1.26539578    1
#> [34,]       1  1   1   0 1.82193047    1
#> [35,]       1  1   1   0 0.82426975    1
#> [36,]       1  1   1   0 0.06910869    1
#> [37,]       1  1   1   0 2.12768646    1
#> [38,]       1  1   1   0 0.17604754    1
#> [39,]       1  1   1   0 0.79667592    1
#> [40,]       1  1   1   0 0.88175568    1
#> [41,]       1  1   1   0 1.90981991    1
#> [42,]       1  1   1   0 2.49322197    1
#> [43,]       1  1   1   0 6.08194002    1
#> [44,]       1  1   1   0 0.46657596    1
#> [45,]       1  1   1   0 4.42061679    1
#> [46,]       1  1   1   0 0.06974186    1
#> [47,]       1  1   1   0 0.80831421    1
#> [48,]       1  1   1   0 1.93941515    1
#> [49,]       1  1   1   0 2.53841657    1
#> [50,]       1  1   1   0 1.62590669    1
#> [51,]       1  1   1   0 0.01341004    1
#> [52,]       1  1   1   0 1.28301573    1
#> [53,]       1  1   1   0 5.86326198    1
#> [54,]       1  1   1   0 0.33130293    1
#> [55,]       1  1   1   0 3.17788464    1
#> [56,]       1  1   1   0 0.12312887    1
#> [57,]       1  1   1   0 2.26948856    1
#> [58,]       1  1   1   0 2.18757794    1
#> [59,]       1  1   1   0 3.52413285    1
#> [60,]       1  1   1   0 2.81137151    1
#> [61,]       1  1   1   0 0.48474830    1
#> [62,]       1  1   1   0 0.41307055    1
#> [63,]       1  1   1   0 0.51943528    1
#> [64,]       1  1   1   0 3.19192160    1
#> [65,]       1  1   1   0 0.88419719    1
#> [66,]       1  1   1   0 0.59463623    1
#> [67,]       1  1   1   0 2.51121114    1
#> [68,]       1  1   1   0 3.50130538    1
#> [69,]       1  1   1   0 0.45907356    0
#> [70,]       1  1   1   0 0.82681640    1
#> 
#> [[7]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]       1  1   0   1  3.71070631    1
#>  [2,]       1  1   0   1  1.07726998    1
#>  [3,]       1  1   0   1  2.92616352    1
#>  [4,]       1  1   0   1  3.05341290    1
#>  [5,]       1  1   0   1  0.07845199    1
#>  [6,]       1  1   0   1  3.20701192    0
#>  [7,]       1  1   0   1  0.30905678    1
#>  [8,]       1  1   0   1  4.63345194    1
#>  [9,]       1  1   0   1  3.96449215    1
#> [10,]       1  1   0   1  1.78641655    1
#> [11,]       1  1   0   1  1.36534068    1
#> [12,]       1  1   0   1  0.30654291    1
#> [13,]       1  1   0   1  0.21476221    1
#> [14,]       1  1   0   1  6.23709896    1
#> [15,]       1  1   0   1  4.27278553    1
#> [16,]       1  1   0   1  0.08709403    0
#> [17,]       1  1   0   1  1.18523982    1
#> [18,]       1  1   0   1  0.50897984    1
#> [19,]       1  1   0   1  2.76824526    1
#> [20,]       1  1   0   1  0.52478831    1
#> [21,]       1  1   0   0  1.50619635    1
#> [22,]       1  1   0   0  2.05205268    1
#> [23,]       1  1   0   0  1.41338247    1
#> [24,]       1  1   0   0  0.80352560    1
#> [25,]       1  1   0   0  0.22859908    1
#> [26,]       1  1   0   0  4.97214382    1
#> [27,]       1  1   0   0  1.85225745    1
#> [28,]       1  1   0   0  0.67089645    1
#> [29,]       1  1   0   0  3.57961963    1
#> [30,]       1  1   0   0 11.59707448    1
#> [31,]       1  1   1   0  0.23451105    1
#> [32,]       1  1   1   0  2.41456971    1
#> [33,]       1  1   1   0  3.33267482    1
#> [34,]       1  1   1   0  2.49279340    1
#> [35,]       1  1   1   0  0.14655533    1
#> [36,]       1  1   1   0  1.65096227    1
#> [37,]       1  1   1   0  0.28454438    1
#> [38,]       1  1   1   0  0.44457895    1
#> [39,]       1  1   1   0  0.82929769    0
#> [40,]       1  1   1   0  2.13870890    1
#> [41,]       1  1   1   0  7.94485561    1
#> [42,]       1  1   1   0  2.28862328    1
#> [43,]       1  1   1   0  2.65370747    1
#> [44,]       1  1   1   0  9.76683125    1
#> [45,]       1  1   1   0  0.13088810    1
#> [46,]       1  1   1   0  5.75197823    1
#> [47,]       1  1   1   0  0.75995659    1
#> [48,]       1  1   1   0  0.18421798    1
#> [49,]       1  1   1   0  1.97027227    1
#> [50,]       1  1   1   0  1.65655960    1
#> [51,]       1  1   1   0  1.27025333    1
#> [52,]       1  1   1   0  3.05304256    1
#> [53,]       1  1   1   0  1.55209991    1
#> [54,]       1  1   1   0  0.20511780    1
#> [55,]       1  1   1   0  1.86073847    1
#> [56,]       1  1   1   0  2.46514171    1
#> [57,]       1  1   1   0  8.97914672    1
#> [58,]       1  1   1   0  0.48439669    1
#> [59,]       1  1   1   0  1.29561315    1
#> [60,]       1  1   1   0  4.77658834    0
#> [61,]       1  1   1   0  2.21835225    1
#> [62,]       1  1   1   0  2.52135707    1
#> [63,]       1  1   1   0  0.54776235    1
#> [64,]       1  1   1   0  1.04629674    1
#> [65,]       1  1   1   0  3.33995660    1
#> [66,]       1  1   1   0  1.13899279    1
#> [67,]       1  1   1   0  0.89796295    1
#> [68,]       1  1   1   0  1.35881826    1
#> [69,]       1  1   1   0  8.93084158    1
#> [70,]       1  1   1   0  0.59007546    1
#> 
#> [[8]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]       1  1   0   1 0.909416673    1
#>  [2,]       1  1   0   1 0.049017342    1
#>  [3,]       1  1   0   1 4.670746854    1
#>  [4,]       1  1   0   1 0.830350723    0
#>  [5,]       1  1   0   1 0.245684934    1
#>  [6,]       1  1   0   1 0.521179897    1
#>  [7,]       1  1   0   1 0.801009936    1
#>  [8,]       1  1   0   1 0.654228450    1
#>  [9,]       1  1   0   1 3.985413506    1
#> [10,]       1  1   0   1 3.085137269    1
#> [11,]       1  1   0   1 0.685586057    1
#> [12,]       1  1   0   1 0.552990199    1
#> [13,]       1  1   0   1 0.006710419    0
#> [14,]       1  1   0   1 3.513785478    1
#> [15,]       1  1   0   1 0.253415948    1
#> [16,]       1  1   0   1 1.225770365    1
#> [17,]       1  1   0   1 2.105023331    1
#> [18,]       1  1   0   1 0.909156513    1
#> [19,]       1  1   0   1 1.386746893    1
#> [20,]       1  1   0   1 0.038183109    1
#> [21,]       1  1   0   0 0.755973830    1
#> [22,]       1  1   0   0 1.532374201    1
#> [23,]       1  1   0   0 0.360499521    0
#> [24,]       1  1   0   0 1.220463498    1
#> [25,]       1  1   0   0 0.240709103    1
#> [26,]       1  1   0   0 0.332050780    0
#> [27,]       1  1   0   0 0.059120261    1
#> [28,]       1  1   0   0 0.361647577    1
#> [29,]       1  1   0   0 0.902277659    1
#> [30,]       1  1   0   0 1.111991563    1
#> [31,]       1  1   1   0 1.522361813    1
#> [32,]       1  1   1   0 0.934224706    1
#> [33,]       1  1   1   0 1.581932100    1
#> [34,]       1  1   1   0 2.631060870    1
#> [35,]       1  1   1   0 0.526507946    1
#> [36,]       1  1   1   0 0.037847988    1
#> [37,]       1  1   1   0 3.421822328    1
#> [38,]       1  1   1   0 2.313397206    1
#> [39,]       1  1   1   0 0.323832450    1
#> [40,]       1  1   1   0 5.599595332    1
#> [41,]       1  1   1   0 1.771193275    0
#> [42,]       1  1   1   0 0.168404304    1
#> [43,]       1  1   1   0 1.693230812    1
#> [44,]       1  1   1   0 0.389240199    0
#> [45,]       1  1   1   0 0.011775033    1
#> [46,]       1  1   1   0 2.945030281    1
#> [47,]       1  1   1   0 1.801439432    1
#> [48,]       1  1   1   0 2.721471528    1
#> [49,]       1  1   1   0 1.581934638    1
#> [50,]       1  1   1   0 1.363053828    1
#> [51,]       1  1   1   0 0.490279534    1
#> [52,]       1  1   1   0 1.734849065    0
#> [53,]       1  1   1   0 1.819634661    1
#> [54,]       1  1   1   0 0.737334248    1
#> [55,]       1  1   1   0 2.000920264    1
#> [56,]       1  1   1   0 0.047485465    1
#> [57,]       1  1   1   0 1.227728376    1
#> [58,]       1  1   1   0 5.372789245    1
#> [59,]       1  1   1   0 7.053717597    1
#> [60,]       1  1   1   0 3.084692940    0
#> [61,]       1  1   1   0 0.335505195    1
#> [62,]       1  1   1   0 1.527053667    1
#> [63,]       1  1   1   0 0.890381536    1
#> [64,]       1  1   1   0 0.466331374    1
#> [65,]       1  1   1   0 1.641057133    1
#> [66,]       1  1   1   0 1.863179374    1
#> [67,]       1  1   1   0 0.045284146    1
#> [68,]       1  1   1   0 1.437751940    1
#> [69,]       1  1   1   0 1.491229083    1
#> [70,]       1  1   1   0 0.404124976    0
#> 
#> [[9]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]       1  1   0   1  0.16347140    1
#>  [2,]       1  1   0   1  0.82158640    1
#>  [3,]       1  1   0   1  0.75463406    1
#>  [4,]       1  1   0   1  0.78967469    1
#>  [5,]       1  1   0   1  1.36223169    1
#>  [6,]       1  1   0   1  0.08776652    1
#>  [7,]       1  1   0   1  1.33325144    1
#>  [8,]       1  1   0   1  2.47337449    1
#>  [9,]       1  1   0   1  0.02422496    1
#> [10,]       1  1   0   1  1.50049119    1
#> [11,]       1  1   0   1  4.15352342    1
#> [12,]       1  1   0   1  0.15022107    1
#> [13,]       1  1   0   1  0.93452380    1
#> [14,]       1  1   0   1  0.93233776    1
#> [15,]       1  1   0   1  4.18975777    1
#> [16,]       1  1   0   1  0.34900534    1
#> [17,]       1  1   0   1  0.12792000    1
#> [18,]       1  1   0   1  0.94836011    1
#> [19,]       1  1   0   1  1.40597557    1
#> [20,]       1  1   0   1  1.48512916    1
#> [21,]       1  1   0   0  0.65111054    1
#> [22,]       1  1   0   0  0.70407907    0
#> [23,]       1  1   0   0  1.38603027    1
#> [24,]       1  1   0   0  0.22931957    1
#> [25,]       1  1   0   0  0.85887849    1
#> [26,]       1  1   0   0  0.87657292    1
#> [27,]       1  1   0   0  2.94843677    1
#> [28,]       1  1   0   0  0.12021535    0
#> [29,]       1  1   0   0  0.29226155    1
#> [30,]       1  1   0   0  2.16017039    1
#> [31,]       1  1   1   0  1.98496630    1
#> [32,]       1  1   1   0  0.88509040    1
#> [33,]       1  1   1   0  0.83668942    1
#> [34,]       1  1   1   0  0.38502067    0
#> [35,]       1  1   1   0  2.80548195    1
#> [36,]       1  1   1   0  0.07531826    0
#> [37,]       1  1   1   0  2.10625327    1
#> [38,]       1  1   1   0  1.40457465    1
#> [39,]       1  1   1   0  2.31500515    1
#> [40,]       1  1   1   0  4.12694118    1
#> [41,]       1  1   1   0  0.90523228    1
#> [42,]       1  1   1   0  2.86758156    1
#> [43,]       1  1   1   0  2.68083131    1
#> [44,]       1  1   1   0  4.77320241    1
#> [45,]       1  1   1   0  1.83684506    1
#> [46,]       1  1   1   0  3.77537571    1
#> [47,]       1  1   1   0  0.03013954    1
#> [48,]       1  1   1   0  5.12470029    1
#> [49,]       1  1   1   0  1.75275394    1
#> [50,]       1  1   1   0  0.47610792    1
#> [51,]       1  1   1   0  0.68940689    1
#> [52,]       1  1   1   0  0.17366082    1
#> [53,]       1  1   1   0  0.34161541    1
#> [54,]       1  1   1   0  2.88290077    1
#> [55,]       1  1   1   0  0.40881566    1
#> [56,]       1  1   1   0  0.06847515    0
#> [57,]       1  1   1   0  1.08860917    0
#> [58,]       1  1   1   0  3.20606536    1
#> [59,]       1  1   1   0  1.58520163    1
#> [60,]       1  1   1   0  0.31192951    0
#> [61,]       1  1   1   0  4.52582767    0
#> [62,]       1  1   1   0  0.14682845    1
#> [63,]       1  1   1   0  1.41025336    1
#> [64,]       1  1   1   0  6.26245573    1
#> [65,]       1  1   1   0  4.45279804    1
#> [66,]       1  1   1   0  2.48504729    1
#> [67,]       1  1   1   0  0.46055801    0
#> [68,]       1  1   1   0  0.12449084    0
#> [69,]       1  1   1   0 10.44075582    1
#> [70,]       1  1   1   0  0.41732223    1
#> 
#> [[10]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]       1  1   0   1  0.15293977    1
#>  [2,]       1  1   0   1  3.58464806    1
#>  [3,]       1  1   0   1  2.33954083    1
#>  [4,]       1  1   0   1  2.72524266    1
#>  [5,]       1  1   0   1  0.92500674    1
#>  [6,]       1  1   0   1  0.73537000    1
#>  [7,]       1  1   0   1  1.00800556    1
#>  [8,]       1  1   0   1  1.23337333    1
#>  [9,]       1  1   0   1  1.22142715    1
#> [10,]       1  1   0   1  3.77491463    1
#> [11,]       1  1   0   1  2.23708702    1
#> [12,]       1  1   0   1  1.02570628    1
#> [13,]       1  1   0   1  0.39496521    1
#> [14,]       1  1   0   1  0.52458831    1
#> [15,]       1  1   0   1  0.23150593    1
#> [16,]       1  1   0   1  1.06322060    1
#> [17,]       1  1   0   1  2.22712514    1
#> [18,]       1  1   0   1  3.23572208    1
#> [19,]       1  1   0   1  0.89551245    1
#> [20,]       1  1   0   1  1.99910315    1
#> [21,]       1  1   0   0  0.22766105    1
#> [22,]       1  1   0   0  5.69339302    1
#> [23,]       1  1   0   0  4.32897026    1
#> [24,]       1  1   0   0  1.31530658    1
#> [25,]       1  1   0   0  4.96276708    1
#> [26,]       1  1   0   0  0.10369898    1
#> [27,]       1  1   0   0 10.54600069    1
#> [28,]       1  1   0   0  0.06541218    0
#> [29,]       1  1   0   0  1.62672049    0
#> [30,]       1  1   0   0  0.82693628    1
#> [31,]       1  1   1   0  0.97869913    1
#> [32,]       1  1   1   0  1.92280904    1
#> [33,]       1  1   1   0  0.04700363    1
#> [34,]       1  1   1   0  0.81308181    1
#> [35,]       1  1   1   0  1.04139306    1
#> [36,]       1  1   1   0  3.30260021    1
#> [37,]       1  1   1   0  0.74434064    1
#> [38,]       1  1   1   0  2.66466718    1
#> [39,]       1  1   1   0  2.44169533    1
#> [40,]       1  1   1   0  4.40171712    1
#> [41,]       1  1   1   0  2.44220054    1
#> [42,]       1  1   1   0  1.24634947    1
#> [43,]       1  1   1   0  2.57407994    1
#> [44,]       1  1   1   0  0.90980343    1
#> [45,]       1  1   1   0  0.09684440    1
#> [46,]       1  1   1   0  3.00351332    1
#> [47,]       1  1   1   0  2.71613652    1
#> [48,]       1  1   1   0  1.67496898    1
#> [49,]       1  1   1   0  0.94115601    1
#> [50,]       1  1   1   0  0.12211408    1
#> [51,]       1  1   1   0  0.35241694    1
#> [52,]       1  1   1   0  0.91811237    1
#> [53,]       1  1   1   0  3.79160895    1
#> [54,]       1  1   1   0  7.28809345    1
#> [55,]       1  1   1   0  2.74971573    1
#> [56,]       1  1   1   0  1.85973787    1
#> [57,]       1  1   1   0  0.02238223    1
#> [58,]       1  1   1   0  3.47364875    1
#> [59,]       1  1   1   0  6.20886144    1
#> [60,]       1  1   1   0  0.42536164    1
#> [61,]       1  1   1   0  2.20164711    1
#> [62,]       1  1   1   0  1.54862447    1
#> [63,]       1  1   1   0  5.44955246    1
#> [64,]       1  1   1   0  2.43647175    1
#> [65,]       1  1   1   0  0.84218526    1
#> [66,]       1  1   1   0  0.61183857    1
#> [67,]       1  1   1   0  0.20071463    0
#> [68,]       1  1   1   0  2.22951022    1
#> [69,]       1  1   1   0  2.15403825    1
#> [70,]       1  1   1   0  1.16798906    1
#> 
#> [[11]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]     1.2  1   0   1 2.441225875    1
#>  [2,]     1.2  1   0   1 4.385189142    1
#>  [3,]     1.2  1   0   1 0.287342827    1
#>  [4,]     1.2  1   0   1 0.714093367    1
#>  [5,]     1.2  1   0   1 3.965487987    1
#>  [6,]     1.2  1   0   1 0.269977211    1
#>  [7,]     1.2  1   0   1 0.437645355    1
#>  [8,]     1.2  1   0   1 0.002246648    1
#>  [9,]     1.2  1   0   1 8.562220765    1
#> [10,]     1.2  1   0   1 0.320355512    1
#> [11,]     1.2  1   0   1 0.668136766    1
#> [12,]     1.2  1   0   1 0.163731670    1
#> [13,]     1.2  1   0   1 1.491876152    1
#> [14,]     1.2  1   0   1 0.300186026    1
#> [15,]     1.2  1   0   1 1.152441043    1
#> [16,]     1.2  1   0   1 0.230822621    1
#> [17,]     1.2  1   0   1 0.245677337    1
#> [18,]     1.2  1   0   1 0.477294451    1
#> [19,]     1.2  1   0   1 0.159093599    1
#> [20,]     1.2  1   0   1 3.423878322    1
#> [21,]     1.2  1   0   0 1.130863185    0
#> [22,]     1.2  1   0   0 6.821780473    1
#> [23,]     1.2  1   0   0 2.956543598    1
#> [24,]     1.2  1   0   0 0.105246697    1
#> [25,]     1.2  1   0   0 0.695268050    0
#> [26,]     1.2  1   0   0 0.327081559    1
#> [27,]     1.2  1   0   0 3.545641504    1
#> [28,]     1.2  1   0   0 0.506231482    1
#> [29,]     1.2  1   0   0 0.333508489    1
#> [30,]     1.2  1   0   0 0.118729976    1
#> [31,]     1.2  1   1   0 0.184896679    1
#> [32,]     1.2  1   1   0 6.902815535    1
#> [33,]     1.2  1   1   0 0.532352843    0
#> [34,]     1.2  1   1   0 1.671818681    1
#> [35,]     1.2  1   1   0 1.344712794    1
#> [36,]     1.2  1   1   0 0.313438120    1
#> [37,]     1.2  1   1   0 1.429636704    1
#> [38,]     1.2  1   1   0 4.012976861    0
#> [39,]     1.2  1   1   0 5.142008263    1
#> [40,]     1.2  1   1   0 1.239647327    1
#> [41,]     1.2  1   1   0 0.136988530    1
#> [42,]     1.2  1   1   0 2.021854579    1
#> [43,]     1.2  1   1   0 0.480315869    0
#> [44,]     1.2  1   1   0 0.621597080    1
#> [45,]     1.2  1   1   0 2.151242558    1
#> [46,]     1.2  1   1   0 6.604513809    1
#> [47,]     1.2  1   1   0 0.402089102    1
#> [48,]     1.2  1   1   0 0.842613326    0
#> [49,]     1.2  1   1   0 3.642875235    1
#> [50,]     1.2  1   1   0 0.655838531    1
#> [51,]     1.2  1   1   0 0.132699467    1
#> [52,]     1.2  1   1   0 2.394220099    1
#> [53,]     1.2  1   1   0 2.222924979    1
#> [54,]     1.2  1   1   0 0.642106420    0
#> [55,]     1.2  1   1   0 0.963472812    0
#> [56,]     1.2  1   1   0 0.106801928    1
#> [57,]     1.2  1   1   0 0.739748243    1
#> [58,]     1.2  1   1   0 1.159691519    1
#> [59,]     1.2  1   1   0 0.879597541    1
#> [60,]     1.2  1   1   0 2.298587862    1
#> [61,]     1.2  1   1   0 0.046133045    1
#> [62,]     1.2  1   1   0 0.957004314    1
#> [63,]     1.2  1   1   0 1.267789890    1
#> [64,]     1.2  1   1   0 2.942888803    1
#> [65,]     1.2  1   1   0 0.906801056    1
#> [66,]     1.2  1   1   0 4.330692682    1
#> [67,]     1.2  1   1   0 2.837703183    1
#> [68,]     1.2  1   1   0 1.459232797    1
#> [69,]     1.2  1   1   0 0.635599085    1
#> [70,]     1.2  1   1   0 0.575183800    1
#> 
#> [[12]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]     1.2  1   0   1  0.73888710    1
#>  [2,]     1.2  1   0   1  0.18418704    1
#>  [3,]     1.2  1   0   1  1.19286669    1
#>  [4,]     1.2  1   0   1  0.29924169    1
#>  [5,]     1.2  1   0   1  2.28973901    1
#>  [6,]     1.2  1   0   1  3.82197135    1
#>  [7,]     1.2  1   0   1  1.44792670    1
#>  [8,]     1.2  1   0   1  2.90510832    1
#>  [9,]     1.2  1   0   1  0.85038709    1
#> [10,]     1.2  1   0   1  1.17414623    1
#> [11,]     1.2  1   0   1  0.28767460    1
#> [12,]     1.2  1   0   1  0.30572126    0
#> [13,]     1.2  1   0   1  0.16813433    1
#> [14,]     1.2  1   0   1  0.36014103    0
#> [15,]     1.2  1   0   1  3.44390294    1
#> [16,]     1.2  1   0   1  3.65494255    1
#> [17,]     1.2  1   0   1  3.03626151    1
#> [18,]     1.2  1   0   1  2.72494085    1
#> [19,]     1.2  1   0   1  0.50793984    1
#> [20,]     1.2  1   0   1  0.39995593    1
#> [21,]     1.2  1   0   0  1.00606776    1
#> [22,]     1.2  1   0   0  2.32856962    1
#> [23,]     1.2  1   0   0  0.33853240    1
#> [24,]     1.2  1   0   0  3.44533321    1
#> [25,]     1.2  1   0   0  0.76273998    1
#> [26,]     1.2  1   0   0  0.56996877    1
#> [27,]     1.2  1   0   0  0.40418001    0
#> [28,]     1.2  1   0   0  0.96698077    1
#> [29,]     1.2  1   0   0  1.11277357    1
#> [30,]     1.2  1   0   0  7.79328648    1
#> [31,]     1.2  1   1   0  0.30809237    1
#> [32,]     1.2  1   1   0  0.60244047    1
#> [33,]     1.2  1   1   0  0.61824456    1
#> [34,]     1.2  1   1   0  1.78795938    1
#> [35,]     1.2  1   1   0  0.33702248    1
#> [36,]     1.2  1   1   0  3.29291537    1
#> [37,]     1.2  1   1   0  1.29833217    1
#> [38,]     1.2  1   1   0  1.93185838    1
#> [39,]     1.2  1   1   0  0.23266095    1
#> [40,]     1.2  1   1   0  1.72376893    1
#> [41,]     1.2  1   1   0  0.69630618    1
#> [42,]     1.2  1   1   0  0.72567581    0
#> [43,]     1.2  1   1   0  0.95446434    1
#> [44,]     1.2  1   1   0  2.22321820    1
#> [45,]     1.2  1   1   0  0.38664684    1
#> [46,]     1.2  1   1   0  1.05477542    1
#> [47,]     1.2  1   1   0  4.52410046    0
#> [48,]     1.2  1   1   0  6.17589522    1
#> [49,]     1.2  1   1   0  0.72150757    1
#> [50,]     1.2  1   1   0  4.02465834    1
#> [51,]     1.2  1   1   0  0.06957838    0
#> [52,]     1.2  1   1   0  0.33423593    1
#> [53,]     1.2  1   1   0  0.15255184    1
#> [54,]     1.2  1   1   0  0.27758938    1
#> [55,]     1.2  1   1   0  4.01726083    1
#> [56,]     1.2  1   1   0  0.76534752    0
#> [57,]     1.2  1   1   0  2.50051346    1
#> [58,]     1.2  1   1   0  1.32367124    1
#> [59,]     1.2  1   1   0  0.91001177    1
#> [60,]     1.2  1   1   0 12.47759863    1
#> [61,]     1.2  1   1   0  0.21564910    0
#> [62,]     1.2  1   1   0  0.56543400    1
#> [63,]     1.2  1   1   0  0.49714725    1
#> [64,]     1.2  1   1   0  2.49069851    0
#> [65,]     1.2  1   1   0  0.19394350    1
#> [66,]     1.2  1   1   0  0.35325062    1
#> [67,]     1.2  1   1   0  0.76322896    1
#> [68,]     1.2  1   1   0  6.01700333    0
#> [69,]     1.2  1   1   0  2.08493919    1
#> [70,]     1.2  1   1   0  1.44582258    1
#> 
#> [[13]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]     1.2  1   0   1 0.248910311    1
#>  [2,]     1.2  1   0   1 0.662524272    1
#>  [3,]     1.2  1   0   1 3.335683051    1
#>  [4,]     1.2  1   0   1 3.070533035    1
#>  [5,]     1.2  1   0   1 3.902257018    1
#>  [6,]     1.2  1   0   1 3.351007406    1
#>  [7,]     1.2  1   0   1 0.876553992    1
#>  [8,]     1.2  1   0   1 6.304266815    0
#>  [9,]     1.2  1   0   1 0.109475027    1
#> [10,]     1.2  1   0   1 0.103733405    1
#> [11,]     1.2  1   0   1 0.210050633    0
#> [12,]     1.2  1   0   1 0.419020103    0
#> [13,]     1.2  1   0   1 0.909371978    1
#> [14,]     1.2  1   0   1 0.502655893    0
#> [15,]     1.2  1   0   1 0.961993113    1
#> [16,]     1.2  1   0   1 0.449502991    1
#> [17,]     1.2  1   0   1 0.232466626    0
#> [18,]     1.2  1   0   1 1.124083682    1
#> [19,]     1.2  1   0   1 1.977034512    1
#> [20,]     1.2  1   0   1 0.851504353    0
#> [21,]     1.2  1   0   0 0.618562889    1
#> [22,]     1.2  1   0   0 0.670931682    1
#> [23,]     1.2  1   0   0 0.876666853    1
#> [24,]     1.2  1   0   0 1.684813765    1
#> [25,]     1.2  1   0   0 0.758103865    1
#> [26,]     1.2  1   0   0 0.752792514    1
#> [27,]     1.2  1   0   0 1.724718805    1
#> [28,]     1.2  1   0   0 3.620880551    1
#> [29,]     1.2  1   0   0 0.863233088    0
#> [30,]     1.2  1   0   0 0.900702495    1
#> [31,]     1.2  1   1   0 1.061132383    1
#> [32,]     1.2  1   1   0 0.626847820    1
#> [33,]     1.2  1   1   0 0.568822198    1
#> [34,]     1.2  1   1   0 0.035520124    1
#> [35,]     1.2  1   1   0 0.169196127    0
#> [36,]     1.2  1   1   0 1.145537306    1
#> [37,]     1.2  1   1   0 0.207483627    1
#> [38,]     1.2  1   1   0 1.787855824    1
#> [39,]     1.2  1   1   0 0.335587504    1
#> [40,]     1.2  1   1   0 0.236521182    1
#> [41,]     1.2  1   1   0 1.295738534    1
#> [42,]     1.2  1   1   0 0.543319964    0
#> [43,]     1.2  1   1   0 1.520512327    1
#> [44,]     1.2  1   1   0 1.536466706    1
#> [45,]     1.2  1   1   0 1.067981264    1
#> [46,]     1.2  1   1   0 0.088592741    0
#> [47,]     1.2  1   1   0 1.994199084    1
#> [48,]     1.2  1   1   0 3.356872700    1
#> [49,]     1.2  1   1   0 0.185550833    1
#> [50,]     1.2  1   1   0 3.886062864    1
#> [51,]     1.2  1   1   0 1.488971256    1
#> [52,]     1.2  1   1   0 0.994370203    0
#> [53,]     1.2  1   1   0 0.141057375    1
#> [54,]     1.2  1   1   0 3.335722975    1
#> [55,]     1.2  1   1   0 0.041923045    1
#> [56,]     1.2  1   1   0 0.273585314    1
#> [57,]     1.2  1   1   0 0.872600890    1
#> [58,]     1.2  1   1   0 1.288242900    1
#> [59,]     1.2  1   1   0 0.030766464    1
#> [60,]     1.2  1   1   0 3.468679741    1
#> [61,]     1.2  1   1   0 0.476357548    1
#> [62,]     1.2  1   1   0 0.004769078    1
#> [63,]     1.2  1   1   0 2.169511245    1
#> [64,]     1.2  1   1   0 2.872605818    1
#> [65,]     1.2  1   1   0 1.068729407    1
#> [66,]     1.2  1   1   0 2.622513415    0
#> [67,]     1.2  1   1   0 1.094735692    1
#> [68,]     1.2  1   1   0 3.923620373    1
#> [69,]     1.2  1   1   0 0.252111968    1
#> [70,]     1.2  1   1   0 0.875037441    1
#> 
#> [[14]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]     1.2  1   0   1 0.642138251    1
#>  [2,]     1.2  1   0   1 3.058544997    1
#>  [3,]     1.2  1   0   1 1.191043835    1
#>  [4,]     1.2  1   0   1 1.270833884    1
#>  [5,]     1.2  1   0   1 4.218252253    1
#>  [6,]     1.2  1   0   1 1.132741020    1
#>  [7,]     1.2  1   0   1 1.224856896    1
#>  [8,]     1.2  1   0   1 0.048271592    1
#>  [9,]     1.2  1   0   1 0.636226407    1
#> [10,]     1.2  1   0   1 8.579757906    1
#> [11,]     1.2  1   0   1 3.459629316    1
#> [12,]     1.2  1   0   1 0.618625882    1
#> [13,]     1.2  1   0   1 1.176258896    1
#> [14,]     1.2  1   0   1 0.332547616    1
#> [15,]     1.2  1   0   1 1.401583728    1
#> [16,]     1.2  1   0   1 0.935104087    1
#> [17,]     1.2  1   0   1 1.029928039    1
#> [18,]     1.2  1   0   1 2.309429761    1
#> [19,]     1.2  1   0   1 1.830447830    1
#> [20,]     1.2  1   0   1 5.507530894    1
#> [21,]     1.2  1   0   0 1.896527538    1
#> [22,]     1.2  1   0   0 2.173987355    1
#> [23,]     1.2  1   0   0 8.003214132    1
#> [24,]     1.2  1   0   0 2.029999401    1
#> [25,]     1.2  1   0   0 0.340442020    1
#> [26,]     1.2  1   0   0 0.559145318    1
#> [27,]     1.2  1   0   0 0.440094329    1
#> [28,]     1.2  1   0   0 1.749501280    1
#> [29,]     1.2  1   0   0 0.094331476    1
#> [30,]     1.2  1   0   0 0.718773647    1
#> [31,]     1.2  1   1   0 0.260883351    1
#> [32,]     1.2  1   1   0 0.266721872    0
#> [33,]     1.2  1   1   0 2.715482425    1
#> [34,]     1.2  1   1   0 6.799490749    1
#> [35,]     1.2  1   1   0 0.555002945    0
#> [36,]     1.2  1   1   0 0.019343823    1
#> [37,]     1.2  1   1   0 2.236106533    1
#> [38,]     1.2  1   1   0 3.754843190    1
#> [39,]     1.2  1   1   0 2.699655672    1
#> [40,]     1.2  1   1   0 1.182085748    0
#> [41,]     1.2  1   1   0 2.148343416    1
#> [42,]     1.2  1   1   0 0.794252314    1
#> [43,]     1.2  1   1   0 0.098610245    1
#> [44,]     1.2  1   1   0 1.008410149    0
#> [45,]     1.2  1   1   0 3.266220710    0
#> [46,]     1.2  1   1   0 0.054636673    1
#> [47,]     1.2  1   1   0 0.799760151    1
#> [48,]     1.2  1   1   0 0.243685204    0
#> [49,]     1.2  1   1   0 0.346628414    1
#> [50,]     1.2  1   1   0 1.222499523    1
#> [51,]     1.2  1   1   0 0.858120954    0
#> [52,]     1.2  1   1   0 0.008744275    1
#> [53,]     1.2  1   1   0 1.405011680    1
#> [54,]     1.2  1   1   0 1.004573748    1
#> [55,]     1.2  1   1   0 0.452985334    1
#> [56,]     1.2  1   1   0 1.427590062    1
#> [57,]     1.2  1   1   0 1.724874498    1
#> [58,]     1.2  1   1   0 1.258052981    1
#> [59,]     1.2  1   1   0 1.211472851    1
#> [60,]     1.2  1   1   0 0.386464084    1
#> [61,]     1.2  1   1   0 0.380514201    1
#> [62,]     1.2  1   1   0 1.805687012    1
#> [63,]     1.2  1   1   0 0.416144836    1
#> [64,]     1.2  1   1   0 0.123479112    1
#> [65,]     1.2  1   1   0 0.940064549    1
#> [66,]     1.2  1   1   0 2.098574622    1
#> [67,]     1.2  1   1   0 0.124181570    0
#> [68,]     1.2  1   1   0 0.450210300    1
#> [69,]     1.2  1   1   0 0.601759042    1
#> [70,]     1.2  1   1   0 0.609939799    1
#> 
#> [[15]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]     1.2  1   0   1 0.65426791    1
#>  [2,]     1.2  1   0   1 1.05044817    1
#>  [3,]     1.2  1   0   1 1.09723459    1
#>  [4,]     1.2  1   0   1 2.93761060    1
#>  [5,]     1.2  1   0   1 0.66833042    1
#>  [6,]     1.2  1   0   1 0.58693138    1
#>  [7,]     1.2  1   0   1 0.18325974    1
#>  [8,]     1.2  1   0   1 0.55699662    1
#>  [9,]     1.2  1   0   1 0.68060111    1
#> [10,]     1.2  1   0   1 4.28052288    1
#> [11,]     1.2  1   0   1 0.61777138    1
#> [12,]     1.2  1   0   1 3.84458223    1
#> [13,]     1.2  1   0   1 0.45220441    1
#> [14,]     1.2  1   0   1 0.25884651    1
#> [15,]     1.2  1   0   1 1.66433998    1
#> [16,]     1.2  1   0   1 3.09282607    1
#> [17,]     1.2  1   0   1 1.31678712    1
#> [18,]     1.2  1   0   1 0.96529547    1
#> [19,]     1.2  1   0   1 0.59203742    1
#> [20,]     1.2  1   0   1 4.43169813    1
#> [21,]     1.2  1   0   0 3.96127434    1
#> [22,]     1.2  1   0   0 0.42136590    1
#> [23,]     1.2  1   0   0 2.91614902    1
#> [24,]     1.2  1   0   0 7.25938312    1
#> [25,]     1.2  1   0   0 0.48745616    0
#> [26,]     1.2  1   0   0 1.09504160    1
#> [27,]     1.2  1   0   0 0.44639671    1
#> [28,]     1.2  1   0   0 2.44161088    1
#> [29,]     1.2  1   0   0 0.95523410    1
#> [30,]     1.2  1   0   0 1.00891820    1
#> [31,]     1.2  1   1   0 2.30534716    1
#> [32,]     1.2  1   1   0 0.13066006    1
#> [33,]     1.2  1   1   0 1.63066680    1
#> [34,]     1.2  1   1   0 2.32335956    1
#> [35,]     1.2  1   1   0 3.34968639    1
#> [36,]     1.2  1   1   0 0.24168566    1
#> [37,]     1.2  1   1   0 0.17053073    0
#> [38,]     1.2  1   1   0 2.30354612    1
#> [39,]     1.2  1   1   0 0.33901738    1
#> [40,]     1.2  1   1   0 3.60631552    1
#> [41,]     1.2  1   1   0 1.81355662    1
#> [42,]     1.2  1   1   0 0.60915390    1
#> [43,]     1.2  1   1   0 0.25278441    0
#> [44,]     1.2  1   1   0 0.35104538    1
#> [45,]     1.2  1   1   0 0.25760814    1
#> [46,]     1.2  1   1   0 0.12598730    0
#> [47,]     1.2  1   1   0 4.84499582    1
#> [48,]     1.2  1   1   0 5.15708275    1
#> [49,]     1.2  1   1   0 0.69913077    1
#> [50,]     1.2  1   1   0 0.33777469    1
#> [51,]     1.2  1   1   0 1.25097790    1
#> [52,]     1.2  1   1   0 0.96406380    0
#> [53,]     1.2  1   1   0 2.62466055    0
#> [54,]     1.2  1   1   0 0.83327949    1
#> [55,]     1.2  1   1   0 0.75080964    0
#> [56,]     1.2  1   1   0 7.35857851    1
#> [57,]     1.2  1   1   0 1.51290995    1
#> [58,]     1.2  1   1   0 3.08736463    1
#> [59,]     1.2  1   1   0 4.05553902    1
#> [60,]     1.2  1   1   0 1.36418400    1
#> [61,]     1.2  1   1   0 2.48911541    1
#> [62,]     1.2  1   1   0 0.54893385    1
#> [63,]     1.2  1   1   0 0.73968950    1
#> [64,]     1.2  1   1   0 0.90854639    1
#> [65,]     1.2  1   1   0 0.52719793    1
#> [66,]     1.2  1   1   0 0.05536161    1
#> [67,]     1.2  1   1   0 0.74129173    1
#> [68,]     1.2  1   1   0 0.47944385    1
#> [69,]     1.2  1   1   0 2.12585548    1
#> [70,]     1.2  1   1   0 1.56510646    1
#> 
#> [[16]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]     1.2  1   0   1 0.21425135    1
#>  [2,]     1.2  1   0   1 3.40896478    1
#>  [3,]     1.2  1   0   1 0.61807424    1
#>  [4,]     1.2  1   0   1 1.25614680    1
#>  [5,]     1.2  1   0   1 0.27271785    1
#>  [6,]     1.2  1   0   1 1.68242208    1
#>  [7,]     1.2  1   0   1 1.01585326    1
#>  [8,]     1.2  1   0   1 0.22350070    1
#>  [9,]     1.2  1   0   1 3.19710759    1
#> [10,]     1.2  1   0   1 0.36570573    1
#> [11,]     1.2  1   0   1 0.01523802    1
#> [12,]     1.2  1   0   1 0.12030288    1
#> [13,]     1.2  1   0   1 0.90501563    1
#> [14,]     1.2  1   0   1 1.61807932    1
#> [15,]     1.2  1   0   1 0.97628322    0
#> [16,]     1.2  1   0   1 0.08506955    1
#> [17,]     1.2  1   0   1 1.57086031    1
#> [18,]     1.2  1   0   1 4.74143794    1
#> [19,]     1.2  1   0   1 1.53108062    1
#> [20,]     1.2  1   0   1 0.05669456    1
#> [21,]     1.2  1   0   0 0.66166929    1
#> [22,]     1.2  1   0   0 1.68026178    1
#> [23,]     1.2  1   0   0 0.53698800    1
#> [24,]     1.2  1   0   0 1.05699809    1
#> [25,]     1.2  1   0   0 0.49543608    1
#> [26,]     1.2  1   0   0 1.47609987    1
#> [27,]     1.2  1   0   0 0.01152874    1
#> [28,]     1.2  1   0   0 0.32578455    1
#> [29,]     1.2  1   0   0 2.84999783    1
#> [30,]     1.2  1   0   0 6.31943084    1
#> [31,]     1.2  1   1   0 1.21355937    1
#> [32,]     1.2  1   1   0 3.63024363    1
#> [33,]     1.2  1   1   0 6.24162498    1
#> [34,]     1.2  1   1   0 0.86995023    1
#> [35,]     1.2  1   1   0 1.72664234    1
#> [36,]     1.2  1   1   0 0.32056094    1
#> [37,]     1.2  1   1   0 0.15229672    1
#> [38,]     1.2  1   1   0 0.27967181    1
#> [39,]     1.2  1   1   0 0.04767076    1
#> [40,]     1.2  1   1   0 3.92256523    1
#> [41,]     1.2  1   1   0 2.88732901    1
#> [42,]     1.2  1   1   0 0.30770134    1
#> [43,]     1.2  1   1   0 4.59057088    0
#> [44,]     1.2  1   1   0 0.22304207    1
#> [45,]     1.2  1   1   0 1.47713946    1
#> [46,]     1.2  1   1   0 0.49257833    0
#> [47,]     1.2  1   1   0 1.31650730    1
#> [48,]     1.2  1   1   0 1.92803243    1
#> [49,]     1.2  1   1   0 0.88772734    1
#> [50,]     1.2  1   1   0 5.88564913    1
#> [51,]     1.2  1   1   0 2.84409453    1
#> [52,]     1.2  1   1   0 3.33457882    1
#> [53,]     1.2  1   1   0 0.12944585    1
#> [54,]     1.2  1   1   0 2.30685924    1
#> [55,]     1.2  1   1   0 0.79155836    0
#> [56,]     1.2  1   1   0 4.32945334    1
#> [57,]     1.2  1   1   0 4.16940084    1
#> [58,]     1.2  1   1   0 0.40612189    1
#> [59,]     1.2  1   1   0 0.51256511    1
#> [60,]     1.2  1   1   0 2.64132695    1
#> [61,]     1.2  1   1   0 0.11732661    1
#> [62,]     1.2  1   1   0 3.53812243    1
#> [63,]     1.2  1   1   0 1.99159778    0
#> [64,]     1.2  1   1   0 0.59849570    1
#> [65,]     1.2  1   1   0 0.11881434    0
#> [66,]     1.2  1   1   0 0.49454524    1
#> [67,]     1.2  1   1   0 2.87044222    1
#> [68,]     1.2  1   1   0 0.79058425    1
#> [69,]     1.2  1   1   0 0.68850767    1
#> [70,]     1.2  1   1   0 0.29943958    1
#> 
#> [[17]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]     1.2  1   0   1  2.66142016    1
#>  [2,]     1.2  1   0   1  0.99074452    1
#>  [3,]     1.2  1   0   1  0.47953781    1
#>  [4,]     1.2  1   0   1  1.22894721    1
#>  [5,]     1.2  1   0   1  0.15178546    1
#>  [6,]     1.2  1   0   1  2.01344363    1
#>  [7,]     1.2  1   0   1  1.35637487    1
#>  [8,]     1.2  1   0   1  1.51560761    1
#>  [9,]     1.2  1   0   1  1.03879538    1
#> [10,]     1.2  1   0   1  0.76309356    1
#> [11,]     1.2  1   0   1  3.97432685    1
#> [12,]     1.2  1   0   1  1.03991097    1
#> [13,]     1.2  1   0   1  0.85610801    1
#> [14,]     1.2  1   0   1  0.08702846    1
#> [15,]     1.2  1   0   1  7.28101594    1
#> [16,]     1.2  1   0   1  1.62825799    1
#> [17,]     1.2  1   0   1  0.67760271    1
#> [18,]     1.2  1   0   1  0.10040503    0
#> [19,]     1.2  1   0   1  3.23284028    1
#> [20,]     1.2  1   0   1  0.22157954    1
#> [21,]     1.2  1   0   0  2.10493433    1
#> [22,]     1.2  1   0   0  0.88377325    0
#> [23,]     1.2  1   0   0  2.66623645    1
#> [24,]     1.2  1   0   0  0.89137299    1
#> [25,]     1.2  1   0   0  1.13721052    1
#> [26,]     1.2  1   0   0  0.38953214    1
#> [27,]     1.2  1   0   0  0.13997293    1
#> [28,]     1.2  1   0   0  2.91874177    1
#> [29,]     1.2  1   0   0  2.54003784    1
#> [30,]     1.2  1   0   0  5.53942325    1
#> [31,]     1.2  1   1   0  4.63539669    1
#> [32,]     1.2  1   1   0  0.40222521    1
#> [33,]     1.2  1   1   0  2.45857359    1
#> [34,]     1.2  1   1   0  0.14645057    0
#> [35,]     1.2  1   1   0  0.33364260    1
#> [36,]     1.2  1   1   0  0.45211046    0
#> [37,]     1.2  1   1   0 11.06726346    1
#> [38,]     1.2  1   1   0  0.41629635    1
#> [39,]     1.2  1   1   0  3.16814991    0
#> [40,]     1.2  1   1   0  2.28902359    1
#> [41,]     1.2  1   1   0  0.87931741    1
#> [42,]     1.2  1   1   0  2.32190707    1
#> [43,]     1.2  1   1   0  0.04828052    1
#> [44,]     1.2  1   1   0  0.21863698    1
#> [45,]     1.2  1   1   0  2.18996270    1
#> [46,]     1.2  1   1   0  2.82274846    1
#> [47,]     1.2  1   1   0  2.97729108    1
#> [48,]     1.2  1   1   0  0.86721579    1
#> [49,]     1.2  1   1   0  1.46810566    1
#> [50,]     1.2  1   1   0  0.58440678    0
#> [51,]     1.2  1   1   0  0.74407995    1
#> [52,]     1.2  1   1   0  6.40907609    1
#> [53,]     1.2  1   1   0  1.77264044    1
#> [54,]     1.2  1   1   0  1.03921504    0
#> [55,]     1.2  1   1   0  0.86397623    1
#> [56,]     1.2  1   1   0  1.54869503    1
#> [57,]     1.2  1   1   0  0.69993481    1
#> [58,]     1.2  1   1   0  1.16664474    1
#> [59,]     1.2  1   1   0  0.10258115    0
#> [60,]     1.2  1   1   0  0.50036998    1
#> [61,]     1.2  1   1   0  1.15492051    1
#> [62,]     1.2  1   1   0  2.68567516    1
#> [63,]     1.2  1   1   0  0.15681566    0
#> [64,]     1.2  1   1   0  0.74217779    1
#> [65,]     1.2  1   1   0  2.18709167    1
#> [66,]     1.2  1   1   0  0.22064268    1
#> [67,]     1.2  1   1   0  2.23821282    1
#> [68,]     1.2  1   1   0 10.46724555    1
#> [69,]     1.2  1   1   0  4.20538418    1
#> [70,]     1.2  1   1   0  0.38353572    1
#> 
#> [[18]]
#>       driftHR HR ext trt        time cnsr
#>  [1,]     1.2  1   0   1 0.562626190    1
#>  [2,]     1.2  1   0   1 0.961916161    1
#>  [3,]     1.2  1   0   1 0.369867706    1
#>  [4,]     1.2  1   0   1 1.084724743    1
#>  [5,]     1.2  1   0   1 2.474261025    1
#>  [6,]     1.2  1   0   1 1.621091477    1
#>  [7,]     1.2  1   0   1 0.606288603    0
#>  [8,]     1.2  1   0   1 1.915161828    1
#>  [9,]     1.2  1   0   1 0.767847928    0
#> [10,]     1.2  1   0   1 0.639575650    1
#> [11,]     1.2  1   0   1 3.441841822    1
#> [12,]     1.2  1   0   1 1.545313302    0
#> [13,]     1.2  1   0   1 1.720148943    1
#> [14,]     1.2  1   0   1 1.445719149    1
#> [15,]     1.2  1   0   1 0.163507510    1
#> [16,]     1.2  1   0   1 1.787002938    1
#> [17,]     1.2  1   0   1 6.330868662    1
#> [18,]     1.2  1   0   1 6.166538930    1
#> [19,]     1.2  1   0   1 2.671912800    1
#> [20,]     1.2  1   0   1 1.156973301    1
#> [21,]     1.2  1   0   0 1.019101975    1
#> [22,]     1.2  1   0   0 4.763115025    1
#> [23,]     1.2  1   0   0 0.984620040    1
#> [24,]     1.2  1   0   0 0.253787346    0
#> [25,]     1.2  1   0   0 3.102694597    1
#> [26,]     1.2  1   0   0 3.680598759    1
#> [27,]     1.2  1   0   0 1.748239664    1
#> [28,]     1.2  1   0   0 5.425105031    1
#> [29,]     1.2  1   0   0 5.184004973    1
#> [30,]     1.2  1   0   0 2.299575223    1
#> [31,]     1.2  1   1   0 3.858274374    1
#> [32,]     1.2  1   1   0 0.764633581    0
#> [33,]     1.2  1   1   0 1.866439657    1
#> [34,]     1.2  1   1   0 2.624097859    1
#> [35,]     1.2  1   1   0 2.273968855    1
#> [36,]     1.2  1   1   0 0.287267931    1
#> [37,]     1.2  1   1   0 3.110372320    1
#> [38,]     1.2  1   1   0 0.373343885    1
#> [39,]     1.2  1   1   0 0.168995715    1
#> [40,]     1.2  1   1   0 3.436525550    1
#> [41,]     1.2  1   1   0 0.985285526    1
#> [42,]     1.2  1   1   0 0.765300053    1
#> [43,]     1.2  1   1   0 0.796751176    1
#> [44,]     1.2  1   1   0 1.579047056    1
#> [45,]     1.2  1   1   0 0.667219451    1
#> [46,]     1.2  1   1   0 0.300413643    0
#> [47,]     1.2  1   1   0 0.465547612    0
#> [48,]     1.2  1   1   0 0.003850348    1
#> [49,]     1.2  1   1   0 0.365616287    1
#> [50,]     1.2  1   1   0 1.803236632    1
#> [51,]     1.2  1   1   0 0.637630957    1
#> [52,]     1.2  1   1   0 0.500640859    0
#> [53,]     1.2  1   1   0 2.782776052    1
#> [54,]     1.2  1   1   0 0.453453923    1
#> [55,]     1.2  1   1   0 0.552211881    1
#> [56,]     1.2  1   1   0 0.840276869    1
#> [57,]     1.2  1   1   0 2.834302895    1
#> [58,]     1.2  1   1   0 0.529657872    1
#> [59,]     1.2  1   1   0 0.084688529    1
#> [60,]     1.2  1   1   0 3.799200527    1
#> [61,]     1.2  1   1   0 6.667296350    1
#> [62,]     1.2  1   1   0 0.557038901    1
#> [63,]     1.2  1   1   0 0.615139544    1
#> [64,]     1.2  1   1   0 2.211149914    1
#> [65,]     1.2  1   1   0 0.612993493    1
#> [66,]     1.2  1   1   0 0.461212103    1
#> [67,]     1.2  1   1   0 0.619969663    0
#> [68,]     1.2  1   1   0 1.068746598    1
#> [69,]     1.2  1   1   0 0.177758675    1
#> [70,]     1.2  1   1   0 1.942172212    1
#> 
#> [[19]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]     1.2  1   0   1 0.75061173    1
#>  [2,]     1.2  1   0   1 0.36633025    1
#>  [3,]     1.2  1   0   1 2.24825339    1
#>  [4,]     1.2  1   0   1 2.93401792    1
#>  [5,]     1.2  1   0   1 0.39762026    1
#>  [6,]     1.2  1   0   1 1.46401373    1
#>  [7,]     1.2  1   0   1 0.35472558    1
#>  [8,]     1.2  1   0   1 0.81690534    0
#>  [9,]     1.2  1   0   1 3.07593242    1
#> [10,]     1.2  1   0   1 3.31760544    1
#> [11,]     1.2  1   0   1 0.54278421    1
#> [12,]     1.2  1   0   1 0.05919315    0
#> [13,]     1.2  1   0   1 1.59864819    1
#> [14,]     1.2  1   0   1 2.40749247    1
#> [15,]     1.2  1   0   1 1.81196117    1
#> [16,]     1.2  1   0   1 2.53796132    1
#> [17,]     1.2  1   0   1 0.01947057    0
#> [18,]     1.2  1   0   1 1.57478743    1
#> [19,]     1.2  1   0   1 1.01690989    1
#> [20,]     1.2  1   0   1 3.12950944    1
#> [21,]     1.2  1   0   0 0.63198769    1
#> [22,]     1.2  1   0   0 0.85278298    1
#> [23,]     1.2  1   0   0 1.48641045    1
#> [24,]     1.2  1   0   0 2.63814346    1
#> [25,]     1.2  1   0   0 1.09173255    1
#> [26,]     1.2  1   0   0 6.14195831    1
#> [27,]     1.2  1   0   0 2.21236132    1
#> [28,]     1.2  1   0   0 2.11171851    1
#> [29,]     1.2  1   0   0 0.14692098    1
#> [30,]     1.2  1   0   0 5.76980908    1
#> [31,]     1.2  1   1   0 0.09095091    1
#> [32,]     1.2  1   1   0 1.03955357    1
#> [33,]     1.2  1   1   0 0.21254568    1
#> [34,]     1.2  1   1   0 2.42007371    1
#> [35,]     1.2  1   1   0 0.39137899    1
#> [36,]     1.2  1   1   0 2.11018066    1
#> [37,]     1.2  1   1   0 3.04882351    1
#> [38,]     1.2  1   1   0 0.92413744    1
#> [39,]     1.2  1   1   0 4.23891279    1
#> [40,]     1.2  1   1   0 0.19342294    1
#> [41,]     1.2  1   1   0 3.61551968    1
#> [42,]     1.2  1   1   0 2.26566493    1
#> [43,]     1.2  1   1   0 0.30681969    0
#> [44,]     1.2  1   1   0 3.61331564    1
#> [45,]     1.2  1   1   0 0.84538690    1
#> [46,]     1.2  1   1   0 0.35870152    1
#> [47,]     1.2  1   1   0 0.24000288    1
#> [48,]     1.2  1   1   0 0.16439279    1
#> [49,]     1.2  1   1   0 0.09430800    1
#> [50,]     1.2  1   1   0 0.55494517    1
#> [51,]     1.2  1   1   0 2.39670059    1
#> [52,]     1.2  1   1   0 0.88886989    1
#> [53,]     1.2  1   1   0 1.08237193    1
#> [54,]     1.2  1   1   0 0.12778621    1
#> [55,]     1.2  1   1   0 0.75886826    0
#> [56,]     1.2  1   1   0 0.44279719    1
#> [57,]     1.2  1   1   0 2.29968074    1
#> [58,]     1.2  1   1   0 0.45653062    1
#> [59,]     1.2  1   1   0 1.01214943    1
#> [60,]     1.2  1   1   0 6.43539384    1
#> [61,]     1.2  1   1   0 0.63677920    1
#> [62,]     1.2  1   1   0 0.40199441    1
#> [63,]     1.2  1   1   0 1.44250392    1
#> [64,]     1.2  1   1   0 1.97974887    1
#> [65,]     1.2  1   1   0 0.46344339    1
#> [66,]     1.2  1   1   0 5.45154228    1
#> [67,]     1.2  1   1   0 1.87763232    1
#> [68,]     1.2  1   1   0 0.19492187    1
#> [69,]     1.2  1   1   0 0.63415833    0
#> [70,]     1.2  1   1   0 0.72384988    1
#> 
#> [[20]]
#>       driftHR HR ext trt       time cnsr
#>  [1,]     1.2  1   0   1 2.20461919    1
#>  [2,]     1.2  1   0   1 1.75051883    1
#>  [3,]     1.2  1   0   1 0.91383990    1
#>  [4,]     1.2  1   0   1 0.38099006    1
#>  [5,]     1.2  1   0   1 0.12036588    1
#>  [6,]     1.2  1   0   1 0.40022153    1
#>  [7,]     1.2  1   0   1 0.45828075    1
#>  [8,]     1.2  1   0   1 0.55345835    1
#>  [9,]     1.2  1   0   1 1.14548763    1
#> [10,]     1.2  1   0   1 1.12603254    1
#> [11,]     1.2  1   0   1 1.31953640    1
#> [12,]     1.2  1   0   1 0.24164706    0
#> [13,]     1.2  1   0   1 1.30672678    1
#> [14,]     1.2  1   0   1 1.95639670    1
#> [15,]     1.2  1   0   1 0.31828571    1
#> [16,]     1.2  1   0   1 0.92515890    1
#> [17,]     1.2  1   0   1 2.16353772    1
#> [18,]     1.2  1   0   1 2.62656447    1
#> [19,]     1.2  1   0   1 4.19276279    1
#> [20,]     1.2  1   0   1 0.14673363    1
#> [21,]     1.2  1   0   0 0.17280555    1
#> [22,]     1.2  1   0   0 1.91602067    1
#> [23,]     1.2  1   0   0 1.16984873    1
#> [24,]     1.2  1   0   0 1.73875908    1
#> [25,]     1.2  1   0   0 0.02299534    1
#> [26,]     1.2  1   0   0 0.41839951    1
#> [27,]     1.2  1   0   0 1.46958804    1
#> [28,]     1.2  1   0   0 4.73484804    0
#> [29,]     1.2  1   0   0 0.49822302    1
#> [30,]     1.2  1   0   0 0.75648357    1
#> [31,]     1.2  1   1   0 4.35947253    1
#> [32,]     1.2  1   1   0 1.42637078    1
#> [33,]     1.2  1   1   0 3.00059682    1
#> [34,]     1.2  1   1   0 0.60336181    1
#> [35,]     1.2  1   1   0 1.42829249    1
#> [36,]     1.2  1   1   0 0.41174514    1
#> [37,]     1.2  1   1   0 0.83918491    1
#> [38,]     1.2  1   1   0 1.34724494    1
#> [39,]     1.2  1   1   0 2.14139194    1
#> [40,]     1.2  1   1   0 0.59262672    1
#> [41,]     1.2  1   1   0 1.13402767    1
#> [42,]     1.2  1   1   0 3.76453634    1
#> [43,]     1.2  1   1   0 1.49547805    1
#> [44,]     1.2  1   1   0 0.96697214    1
#> [45,]     1.2  1   1   0 1.44451024    1
#> [46,]     1.2  1   1   0 6.58307923    1
#> [47,]     1.2  1   1   0 3.07000239    1
#> [48,]     1.2  1   1   0 6.13983769    1
#> [49,]     1.2  1   1   0 3.31482968    1
#> [50,]     1.2  1   1   0 0.74567398    1
#> [51,]     1.2  1   1   0 1.54025692    1
#> [52,]     1.2  1   1   0 0.86409956    1
#> [53,]     1.2  1   1   0 1.75202038    1
#> [54,]     1.2  1   1   0 0.21394181    1
#> [55,]     1.2  1   1   0 3.60266735    1
#> [56,]     1.2  1   1   0 0.31281427    1
#> [57,]     1.2  1   1   0 0.19093028    1
#> [58,]     1.2  1   1   0 4.16531393    1
#> [59,]     1.2  1   1   0 1.49951445    1
#> [60,]     1.2  1   1   0 0.05974983    1
#> [61,]     1.2  1   1   0 1.56713522    1
#> [62,]     1.2  1   1   0 1.86707461    1
#> [63,]     1.2  1   1   0 0.82444388    0
#> [64,]     1.2  1   1   0 1.58718108    1
#> [65,]     1.2  1   1   0 1.81005257    1
#> [66,]     1.2  1   1   0 1.93938545    1
#> [67,]     1.2  1   1   0 0.45561173    0
#> [68,]     1.2  1   1   0 0.41694782    1
#> [69,]     1.2  1   1   0 5.90992451    1
#> [70,]     1.2  1   1   0 0.93823345    0
#>